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DEPARTMENT OF MOLECULAR BIOCHEMISTRY
1. About the lab
Head: Dr. Le Thi Hong Minh
Tel: 0983085859
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Contact adress: Department of Molecular Biochemistry - Institute of Chemistry - Viet Nam academy of scince and technology - No 18 Hoang Quoc Viet Street, Hanoi, Vietnam.
2. Lab members:
At present, Department of Molecular Biochemistry consists of a total of 7 staff scientists. The staff composition includes 1 Associate Professor, 3 Doctors, 2 Masters, 1 Bachelors.
3. Research areas:
- Investigate and study the composition, molecular structure and biosynthetic pathways of bioactive compounds derived from marine, mangrove, island, and terrestrial environments; determine the relationship between chemical structure and biological activity with a focus on applications in medicine, biology, and pharmaceuticals.
- Scientific research and technological development in the field of microbiology for applications in industry, forestry, agriculture, environmental protection and public health.
- Scientific and technological research in the field of molecular biology to enable scientific identification and genetic manipulation for the creation of products that support socio-economic development.
- Research technological processes for the extraction and synthesis of active compounds and products applicable in pharmaceuticals, cosmetics, food, industry, agriculture and the environment.
- Training for personnel in the field of molecular biochemistry and other related fields.
- International collaboration in the field of molecular biochemistry and other relevant areas.
4. Main achievements:
Marine Microbial Biodiversity:
- Metagenome database of sponge-associated microorganisms from the central coast of Vietnam has been established. A number of new genes from these microorganisms have been discovered and screened. Protocols for gene expression and protein recovery have been developed, targeting proteins involved in the biosynthesis of compounds with antibacterial and protease-inhibitory activities.
- A large collection of marine microorganisms (including bacteria, actinomycetes, and marine fungi) has been isolated and preserved from various marine and island Vietnam.
Secondary Metabolites from Marine Microorganisms:
From the collection of marine microorganisms, several secondary metabolites have been isolated, many of which exhibit significant biological activities such as cytotoxicity against cancer cells, antibiotic effects, and antioxidant properties.
Microbial technology:
In the context of applications in agriculture and aquaculture, several marine microbial strains have been identified with activities including inhibition of Vibrio spp., and the production of protease, phytase, and amylase enzymes. These strains are suitable for developing environmental treatment products and as feed additives in industrial shrimp farming.
Research on the production of recombinant Virus-Like Particle (VLP) Antigens:
Virus-like particle (VLP) antigens with morphology and size of approximately 25 nm—closely resembling real virus particles—have been successfully generated. the antigens produced had different levels of immune response in experimental mice. Among them, the VLP antigen expressed in insect cells carrying the VP0-VP1-2A-VP3 cassette had the best response to foot-and-mouth disease antibodies. Trials on calves demonstrated favorable immunogenicity: at doses of 14.4 µg, 28.8 µg, and 43.2 µg per injection, all three calves in each group tested seropositive by day 28. The antibody titer of the serum obtained at a concentration of 28.8 µg/dose showed that the highest antibody titer in the calf serum was 1/256 and the lowest was 1/32.
- Researched the synthesis of generic pharmaceutical compounds: Imatinib and Linezolid; and synthesized Alphitonin-4-O-β-D-glucopyranoside.
- Developed herbal formulations derived from Smilax glabra and the CbF formulation extracted from Carallia brachiata.
5. Publications:
From 2020 to 2024, our lab published 18 papers in SCIE and Since 2016, six patents have been published.
6. Photos:
DEPARTMENT OF MOLECULAR BIOCHEMISTRY
1. About the lab
Head: Dr. Le Thi Hong Minh
Tel: 0983085859
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Contact adress: Department of Molecular Biochemistry - Institute of Chemistry - Viet Nam academy of scince and technology - No 18 Hoang Quoc Viet Street, Hanoi, Vietnam.
2. Lab members:
At present, Department of Molecular Biochemistry consists of a total of 7 staff scientists. The staff composition includes 1 Associate Professor, 3 Doctors, 2 Masters, 1 Bachelors.
3. Research areas:
- Investigate and study the composition, molecular structure and biosynthetic pathways of bioactive compounds derived from marine, mangrove, island, and terrestrial environments; determine the relationship between chemical structure and biological activity with a focus on applications in medicine, biology, and pharmaceuticals.
- Scientific research and technological development in the field of microbiology for applications in industry, forestry, agriculture, environmental protection and public health.
- Scientific and technological research in the field of molecular biology to enable scientific identification and genetic manipulation for the creation of products that support socio-economic development.
- Research technological processes for the extraction and synthesis of active compounds and products applicable in pharmaceuticals, cosmetics, food, industry, agriculture and the environment.
- Training for personnel in the field of molecular biochemistry and other related fields.
- International collaboration in the field of molecular biochemistry and other relevant areas.
4. Main achievements:
Marine Microbial Biodiversity:
- Metagenome database of sponge-associated microorganisms from the central coast of Vietnam has been established. A number of new genes from these microorganisms have been discovered and screened. Protocols for gene expression and protein recovery have been developed, targeting proteins involved in the biosynthesis of compounds with antibacterial and protease-inhibitory activities.
- A large collection of marine microorganisms (including bacteria, actinomycetes, and marine fungi) has been isolated and preserved from various marine and island Vietnam.
Secondary Metabolites from Marine Microorganisms:
From the collection of marine microorganisms, several secondary metabolites have been isolated, many of which exhibit significant biological activities such as cytotoxicity against cancer cells, antibiotic effects, and antioxidant properties.
Microbial technology:
In the context of applications in agriculture and aquaculture, several marine microbial strains have been identified with activities including inhibition of Vibrio spp., and the production of protease, phytase, and amylase enzymes. These strains are suitable for developing environmental treatment products and as feed additives in industrial shrimp farming.
Research on the production of recombinant Virus-Like Particle (VLP) Antigens:
Virus-like particle (VLP) antigens with morphology and size of approximately 25 nm—closely resembling real virus particles—have been successfully generated. the antigens produced had different levels of immune response in experimental mice. Among them, the VLP antigen expressed in insect cells carrying the VP0-VP1-2A-VP3 cassette had the best response to foot-and-mouth disease antibodies. Trials on calves demonstrated favorable immunogenicity: at doses of 14.4 µg, 28.8 µg, and 43.2 µg per injection, all three calves in each group tested seropositive by day 28. The antibody titer of the serum obtained at a concentration of 28.8 µg/dose showed that the highest antibody titer in the calf serum was 1/256 and the lowest was 1/32.
- Researched the synthesis of generic pharmaceutical compounds: Imatinib and Linezolid; and synthesized Alphitonin-4-O-β-D-glucopyranoside.
- Developed herbal formulations derived from Smilax glabra and the CbF formulation extracted from Carallia brachiata.
5. Publications:
From 2020 to 2024, our lab published 18 papers in SCIE and Since 2016, six patents have been published.
6. Photos:
