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CENTER OF DRUG RESEARCH AND DEVELOPMENT
1. About the Center
Head: Assoc. Prof. Nguyen Xuan Nhiem
Tel: 0984009088
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Contact adress: Room 504, A23 Building, No. 18 Hoang Quoc Viet, Nghia Do, Hanoi
- Lab members:
- Research areas:
- Research to discover bioactive compounds from marine organisms of Vietnam.
- Research to discover bioactive compounds with potential use in medicine and food from natural sources.
- Research to enhance the value of bioactive compounds for development into food, medicines, and specialty drugs for community health care.
- Research to improve technology for large-scale extraction of bioactive compounds from natural sources as raw materials for pharmaceutical industry in Vietnam.
- Research and improvement of manufacturing processes for off-patent specialty drugs for pharmaceutical production.
- Research, development, and application of biological assays in the field of bioactive compounds on in vitro
- Main achievements:
Process for preparing the nano emulsion complex of Malloapelta B-Curcumin.
The Malloapelta B-Curcumin nano emulsion complex, as developed in this invention, has been shown to inhibit cancer cell proliferation in vitro and tumor growth in BALB/c mice. This nano emulsion complex is easily dispersed in water, highly safe, non-toxic, and causes minimal side effects during use. As a result, the process for preparing the Malloapelta B-Curcumin nano emulsion complex provides a valuable scientific foundation for applied research focused on developing products to assist in cancer treatment.
The research results have been granted Patent No. 34958 in 2023.
Nano Mallomin Formulation
The product is formulated as 500 mg soft capsules containing:
- Nano Curcumin 5%: 300 mg (equivalent to 15 mg of Curcumin),
- Dry extract of Mallotus apelta: 60 mg,
- Dry extract of Phyllanthus urinaria: 50 mg,
- Dry extract of Panax pseudoginseng: 50 mg,
along with some other excipients.
It supports the protection of the gastric and duodenal mucosa and helps alleviate symptoms such as abdominal pain, epigastric burning sensation, and acid reflux.
- Publications:
|
STT |
Tên bài báo |
Tên tác giả |
Tên tạp chí |
Năm công bố |
|
1. |
A New Guaianolide‑type Sesquiterpenoid and Xanthine Oxidase |
Ton That Quang, Nguyen Thi Thanh Mai, Le Huu Tho, Truong Nhat Van Do, Vu Mai Thao, Duong Thi Hai Yen, Phan Van Kiem, Bui Huu Tai, Nguyen Thi Minh Hang, Nguyen Xuan Nhiem |
Revista Brasileira de Farmacognosia |
2024 |
|
2. |
Bithiophene and coumestan derivatives from |
Le Thi Giang, SeonJu Park, Nguyen Thi Cuc, Bui Huu Tai, Phan Van Kiem, Nguyen Thi Minh Hang, Ninh Khac Ban, Pham Van Cuong & Nguyen Xuan Nhiem |
Journal of Asian natural products research |
2024 |
|
3. |
Flavonoids glycosides from Camellia phanii |
Ninh Khac Thanh Tung, Hoang Thi Tuyet Lan, Tran Thuy Nga, Nguyen Thi Mai, |
Phytochemistry Letters |
2024 |
|
4. |
Hepatoprotective Lignan Glycosides from the Leaves and |
Le Thi Giang, SeonJu Park, Sion Lee, Yohan Seo, Phan Van Kiem, Bui Huu Tai, |
Chemistry & Biodiversity |
2024 |
|
5. |
Labdane-type diterpenoids and sesquiterpenes |
Nguyen Thi Hien, Dinh Thi Cuc, Nguyen Thi Thanh Thuy, Hoang Hiep, |
Journal of Asian natural products research |
2024 |
|
6. |
Neolignan Glycoside and Other Constituents |
Nong Thi Anh Thu, Lo Huyen Linh, Dao Anh Hoang, Nguyen Tu Oanh, Vu Mai Thao, Nguyen Thi Minh Hang, Nguyen Xuan Nhiem |
Natural Product Communications |
2024 |
|
7. |
Oleanane-type saponins from Lysimachia laxa Baudo |
Nguyen Thi Luyen, Nguyen Tien Dat*, Do Hoang Giang, Nguyen Thi Kim Thuy, Bui Huu Tai, Phan Thi Thanh Huong, Le Thi Phuong Quynh, Duong Thi Thuy, SeonJu Park, and Nguyen Xuan Nhiem |
Bioscience, Biotechnology, and Biochemistry |
2024 |
|
8. |
Oleanane-Type Triterpene Glycosides from Camellia phanii |
Hoang Thi Tuyet Lan, Vu Thi Xuan, Bui Thi Mai Anh, Nguyen Thi Mai, Nguyen Viet Dung, Bui Huu Tai, Nguyen Thi Minh Hang, Vu Mai Thao, Nguyen Xuan Nhiem |
Chemistry & Biodiversity |
2024 |
|
9. |
A new iridoid glucoside from the roots of Morinda |
Le Thi Huyen, Nguyen Thi Hien, Nguyen Viet Duy Anh, Vu Mai Thao, |
Journal of Asian natural products research |
2023 |
|
10. |
Glyasperin A from Macaranga indica Presents Promising Capacities |
Trinh S. Mai, Do Thi Phuong, Nguyen Thi Nga, Nguyen Xuan Nhiem, Nguyen Thi Cuc, Trieu H. Phuong, Nguyen T. Nam, Chu Hoang Ha, Do Thi Thao |
Revista Brasileira de Farmacognosia |
2023 |
|
11. |
Two new neolignans from the roots of Platycodon grandiflorus and their |
Tran Huu Giap, Vu Mai Thao, Nguyen Van Hung, Hoang Thi Minh Hien, Ngo Thi Hoai Thu, Phan Thi Hoa, Nguyen Xuan Nhiem, Nguyen Thi Minh Hang |
Phytochemistry Letters |
2023 |
|
12. |
Isolation of Fucoxanthin from Sargassum oligocystum |
Dang Diem Hong , Le Thi Thom, Nguyen Cam Ha, Ngo Thi Hoai Thu, Hoang Thi Minh Hien, Luu Thi Tam, Nguyen Manh Dat, Tran Mai Duc, Nguyen Van Tru, Nguyen Thi Minh Hang and Ranga Rao Ambati |
Biomedicines |
2023 |
|
13. |
In vitro α-Glucosidase inhibitors of Polyscias serrata Roots in a Parallel Study of Network Pharmacology |
Le Thi Tu Anh, Hoang Thai Dang, Nguyen Thi Thu Ha, Nguyen Thanh Tra, Nguyen Thi Thuy Linh, Ba Thi Cham, Bui Thi Thuy Luyen, Hoang Huy Do, Tiep Khac Nguyen |
Records of Natural Products |
2024 |
|
14. |
New nor-lignans from the leaves of styrax annamensis guillaumin |
Nguyen Thanh Tra, Nguyen Van Tuyen, Nguyen Thi Thu Ha, Ba Thi Cham, Le Thi Tu Anh, Nguyen Thi Thuy Linh, Ninh The Son |
Natural Product Research |
2024 |
|
15. |
Garcimckeans A-C, three new xanthones from the stems of Garcinia mckeaniana, and their cytotoxic activity. |
Nguyen Thi Thu Ha, Nguyen Van Tuyen, Nguyen Thanh Tra, Le Thi Tu Anh, Ninh The Son, Mac Litaudon, Pham Van Cuong, Bui Huu Tai, and Phan Van Kiem, |
Natural Product Research |
2023 |
|
16. |
Oleanane-type triterpenoid sulfates, two new α-glucosidase inhibitors from Elaeocarpus hainanensis. Natural, |
Ba Thi Cham, Vu Dinh Hoang, Nguyen Thi Thuy Linh, Nguyen Thi Thu Hoa, Nguyen Thi Hoang Anh, Bui Huu Tai, Le Thi Hong Nhung, Domenico V Delfino, Trinh Thi Thuy, |
Natural Product Research, |
2023 |
- Photos:
