Department of Structural Research

DEPARTMENT OF STRUCTURAL RESEARCH

      1. About the lab Head: Prof. Bui Huu Tai

Tel:  0971228485

E-Mail:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact adress: 4^th floor, A23 Building, 18 Hoang Quoc Viet, Cau Giay, Ha Noi

2. Lab members:

3. Research areas:

- Investigation on molecular structure of organic compounds

- Investigation on Structure-Bioactivity Relationships

- Application of advanced methods for structure determination of organic compounds

- Scientific services in structure determination of organic compounds

- Training in structure determination of organic compounds

- Collaboration in molecular structure of organic compounds

4. Main achievements:

-Approximately 40 SCIE publications per years

-Identification of novel compounds, new carbon skeleton from marine sponges and terrestrial plants.

-Determination of absolute configurations of natural products using Circular Dichroism spectroscopy

-Stereochemistry determiation of natural products using TD-DFT and GIAO theoretical calculation   

5. Publications:

-Selected SCIE publications

1. Bui Huu Tai, Ngo Anh Bang, Pham Hai Yen, Duong Thi Hai Yen, Nguyen Thi Cuc, Duong Thi Dung, Phan Thi Thanh Huong, Do Thi Trang, Nguyen Xuan Nhiem, Nguyen The Cuong, Phan Van Kiem, Undescribed sesquiterpene-diterpene heterodimers from the fruits of Aphanamixis polystachya selectively modulate inflammatory markers in RAW 264.7 cells, Phytochemistry, 220, 113997 (2024); https://doi.org/10.1016/j.phytochem.2024.113997

2. Pham Hai Yen, Ngo Anh Bang, Do Thi Trang, Duong Thi Hai Yen, Duong Thi Dung, Phan Thi Thanh Huong, Nguyen Huy Hoang, Bui Huu Tai, Le Tuan Anh, Phan Van Kiem, Undescribed 2,9-deoxyflavonoids and flavonol-diamide [3+2] adduct from the leaves of Aglaia odorata Lour. Inhibit nitric oxide production, Phytochemistry, 214, 113792, 2023, https://doi.org/10.1016/j.phytochem.2023.113792; The best reserch paper of 2023 in Chemistry at VAST

3. Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen Huy Hoang, Ngo Anh Bang, Pham Hai Yen, Do Thi Trang, Duong Thi Dung, Nguyen Thi Cuc, Phan Thi Thanh Huong, Bui Huu Tai, Undescribed (2–7′)-neolignans and polyoxygenated cyclohexene glycosides from the aerial parts of Piper mutabile C. DC. and their inhibitory effects on nitric oxide production, Fitoterapia, 175, 105903, 2024, https://doi.org/10.1016/j.fitote.2024.105903

4. Do Thi Trang, Dan Thi Thuy Hang, Duong Thi Dung, Nguyen Thi Cuc, Pham Hai Yen, Phan Thi Thanh Huong, Le Thi Huyen, Nguyen Thi Mai, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Rhabdastrenones A–D from the sponge Rhabdastrella globostellata, RSC Advances, 12, 10646-10652, 2022, https://doi.org/10.1039/D2RA01674E

5. Bui Huu Tai, Pham Hai Yen, Nguyen Huy Hoang, Phan Thi Thanh Huong, Nguyen Viet Dung, Bui Van Thanh, Nguyen The Cuong, Ngo Anh Bang, Nguyen Xuan Nhiem, Phan Van Kiem, New dibenzocyclooctadiene lignans from Kadsura induta with their anti-inflammatory activity, RSC Advances, 12, 5433-25439, 2022, https://doi.org/10.1039/D2RA05052H

-Selected patents

1. Hợp chất 6/6/5/5-tetraxyclic triterpene và phương pháp phân lập hợp chất này từ loài hải miên Rhabdastrella globostellata, Patent Number: 37998 (2023)

2. Hợp chất gymsylosit có tác dụng ức chế enzym α-amylaza, α-glucosidaza và phương pháp phân lập hợp chất này từ loài dây thìa canh Gymnema sylvestre, Patent Number: 29666 (2021)

3. Hợp chất malloapelta và phương pháp phân lập hợp chất này từ loài bùm bụp Mallotus apelta, Patent Number: 36650 (2023)

 - References

https://orcid.org/0000-0003-0756-6990 (Phan Van Kiem)

https://www.webofscience.com/wos/author/record/S-1021-2017 (Bui Huu Tai)

6. Photos: