Vietnamese 
English 
DEPARTMENT OF BIOACTIVE COMPOUNDS
- General information
Head: Tran Quang Hung
Tel: +84. 943175337
E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Contact adress: A18 building, 18 Hoang Quoc Viet street, Caugiay Dist., Ha Noi Capital, Vietnam.
Year of Establishment: 1969
Heads of the Department since establishment:
1. Assoc. Prof. Dr. Pham Hoang Ngoc 1969-2003
2. Prof. Dr. Nguyen Manh Cuong 2003-2007
3. Dr. Nguyen Quyet Tien 2007-2024
4. Dr. Tran Quang Hung Jan 2025 - present
- Staff members:
- Research areas:
- Design and synthesis of novel organic materials: Focusing on applications in optoelectronics, batteries, and electrochromic materials.
- Synthesis and biological activity evaluation of heterocyclic compounds: Including the development of new anti-cancer agents containing heterocyclic pharmacophores and the investigation of the biological activity of newly synthesized heterocyclic compounds.
- Development of novel organic synthesis methods: Emphasizing sustainable synthesis approaches, including research and application of heterogeneous catalysis for the synthesis of biologically active heterocyclic compounds (pharmacophores).
- Natural product chemistry: Including extraction, isolation, and structure elucidation of compounds from natural sources.
- Main achievements:
- Participation in the industrial-scale production of Artemisinin and its derivatives for malaria prevention and control in Vietnam and globally.
- Successful research and production of products, such as the CAFETASO preparation supporting the treatment of kidney and gall stones.
- Products and Services:
- Successful pilot-scale production of the CAFETASO preparation for supporting the treatment of kidney and gall stones.
- Currently undertaking technology transfer to pharmaceutical companies for market expansion to serve therapeutic needs.
- Completed and Ongoing Projects/Grants (excluding institutional-level projects)
|
No. |
Project Title |
Cơ quan phối hợp |
Funding Agency |
Principal Investigator (PI) |
Duration |
|
1. |
Isolation, structure elucidation of active compounds in some folk medicinal plants with anti-malarial, anti-inflammatory, anti-cancer effects. Code: 5.12.104. |
MOST (National Basic Research Program) |
Assoc. Prof. Dr. Pham Hoang Ngoc |
2001 |
|
|
2. |
Extraction, isolation and structure elucidation of active compounds in some Vietnamese folk medicinal plants. Code 5.1.13.06 |
MOST (National Basic Research Program) |
Assoc. Prof. Dr. Pham Hoang Ngoc |
2006 |
|
|
3. |
Production and testing of anti-inflammatory and anti-immunodeficiency effects of some active compounds from Croton tonkinensis in experimental models. |
VAST |
Assoc. Prof. Dr. Pham Hoang Ngoc |
2006 |
|
|
4. |
Study of chemical constituents and biological activities of the genus Schisandra and genus Kadsura, family Schisandraceae in Vietnam. |
NAFOSTED |
Dr. Pham Thi Hong Minh |
2011-2013 |
|
|
5. |
Research on the scientific basis for creating a preparation supporting kidney stone treatment from Coffea arabica leaves. Code: VAST06.02/11/12 |
VAST |
Dr. Nguyen Quyet Tien |
2011-2012 |
|
|
6. |
Production of the functional preparation CAFETASO supporting the treatment of kidney and gall stones from Vietnamese plants. |
Essential Oils and Aromas JSC |
VAST |
Dr. Nguyen Quyet Tien |
2019-2020 |
|
7. |
Research on synthesis and physical property investigation of nitrogen heterocyclic compounds for application in organic semiconductor materials. Code: 104.01-2015.81 |
MOST / NAFOSTED |
Dr. Tran Quang Hung |
2015-2018 |
|
|
8. |
Research on preparation of some heterogeneous catalyst systems applied for sustainable synthesis of heterocyclic pharmacophore compounds. Code: 104.01-2017.320 |
MOST / NAFOSTED |
Dr. Vu Xuan Hoan |
2016-2019 |
|
|
9. |
Research and development of some new optoelectronic organic semiconductor material systems with conjugated aromatic heterocyclic structures. |
MOST / NAFOSTED |
Dr. Tran Quang Hung |
2020-2024 |
|
|
10. |
Development of new electrochromic smart windows for application as automotive heat shields and building energy saving. |
VNUK Institute for Research and Executive Education, University of Danang |
Vingroup Innovation Foundation (VINIF) |
Dr. Le Hoang Sinh |
2020-2024 |
|
11. |
Design and synthesis of novel anti-cancer agents containing heterocyclic pharmacophore groups. Code: 104.01-2024.3 |
MOST / NAFOSTED |
Assoc. Prof. Dr. Dang Thanh Tuan |
2024 |
|
|
12. |
Development of new anti-cancer agents containing heterocyclic pharmacophores. |
Vingroup Innovation Foundation (VINIF) |
Assoc. Prof. Dr. Dang Thanh Tuan |
2021-2024 |
|
|
13. |
Research on synthesis and biological activity evaluation of some new heterocyclic compounds. |
VAST |
Dr. Tran Quang Hung |
2022-2024 |
Scientific Publications (since 2020):
|
No. |
Article Title |
Authors |
Journal Name |
Year |
|
1. |
One-pot acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and evaluation of cytotoxic activities |
T. Q. Hung, B. V. Phuc, H. N. Do, T. H. Tran, H. Y. Nguyen, N. Truong Phuoc, T. M. Chi, D. V. Do, T. T. T. Nga, H. Nguyen, V. T. Nguyen and T. T. Dang |
RSC advances, 2025, 15, 4274-4280. |
2025 |
|
2. |
Design and synthesis of novel beta-carboline-bisindole hybrids as potential anticancer agents |
T. T. Dang, N. T. T. Huyen, B. V. Phuc, T. T. Huyen, T. T. Hong, H. Nguyen, V. H. Nguyen, M. T. Nguyen, T. Q. Hung, C. P. Dinh |
ChemMedChem 2024 Vol. 19 Issue 18 Pages e202400316 |
2024 |
|
3. |
LiOtBu-promoted synthesis of bis(3-indolyl)methanes by the alkylation of indoles with alcohols under air |
H. Y. Nguyen, T. H. Tran, H. N. Do, D. Van Do, Q.-A. Ngo, N. Q. Tien, T. T. Thanh Nga, H. Nguyen, T. Q. Hung, T. T. Dang |
RSC advances 2024, 14, 2341-2345 |
2024 |
|
4. |
3D printed multicolor Prussian blue-viologen hybrid electrochromic devices: Toward high contrast ratio and fast switching electrochromic devices |
L. H. Thai, L. T. T. Nhi, T. C. Giang, N. M. Hiep, T. Q. Trung, T. Q. Hung, L. H. Sinh |
Applied Materials Today 2024, 40, 102369 |
2024 |
|
5. |
Design, synthesise, and evaluate photoluminescent properties of novel 3,6-diphenylpyrazine-2-carbonitrile derivatives |
Bàn Văn Phúc, Hồ Quốc Việt, Đỗ Tuấn Tú, Nguyễn Minh Hoàng, Trần Tuấn Linh, Đặng Thanh Tuấn, Trần Quang Hưng |
Vietnam Journal of Science and Technology - Section B |
2024 |
|
6. |
Synthesis of fused 5H-thiazolo[2',3':2,3]imidazo[4,5-b]indole structures using sequential copper-catalyzed C-N coupling reactions. |
Do Van Dang, Nguyen Linh Chi, Dang Thanh Tuan, Tran Quang Hung |
VNU Journal of Science: Natural Sciences and Technology |
2024 |
|
7. |
A gel-based electrochromic device towards fast response and high coloration efficiency for low-power consumption smart window applications |
L. H. Thai, L. Thi-Thanh-Nhi, T. C. Giang, T. Q. Hung, T. Q. Trung, N. V. Huy, N. M. Hiep, L. H. Sinh |
Org. Electron. 2024, 128, 107040. |
2024 |
|
8. |
Enhanced optical bistability of energy saving viologen-based electrochromic display with a commercial phenol-based epoxy resin |
L. H. Thai, L. T. T. Nhi, T. C. Giang, L. Van Quyet, N. M. Hiep, T. Q. Hung and L. H. Sinh |
Sol. Energy Mater. Sol. Cells,277(2024) 113114. |
2024 |
|
9. |
Synthesis of new DOPO derivatives and investigation of their synergistic effect with APP–PEI on the flame retardancy of epoxy composite |
C. T. Duc, L. C. Nguyen, P. B. Van, H. T. Nguyen, T. A. Dang Thi, G. Le-Nhat-Thuy, Q. G. Nguyen Thi, P. H. Thi, T. A. Nguyen, Q. V. Tran, H. T. Quang, M. H. Hoang and T. N. Van |
RSC advances, 2024, 14, 5264-5275. |
2024 |
|
10. |
Facile Ru-catalysed synthesis of quinazolin-4(3H)-ones by tandem cyclization of 2-nitrobenzonitrile and alcohols derivatives under air |
T. T. Dang, T. Q. Hung, H. Nguyen, B. V. Phuc, Q. A. Ngo, N. T. M. Tuan, T. D. Nguyen, P. A. Dao, P. T. Thao Vy and N. T. Nguyen |
Org. Biomol. Chem., 2024, DOI: 10.1039/D4OB01786B. |
2024 |
|
11. |
Methanol Activation: Strategies for Utilization of Methanol as C1 Building Block in Sustainable Organic Synthesis |
H. V. Tran, T. T. Dang, N. H. Nguyen, H. T. Tran, D. T. Nguyen, D. V. Do, T. S. Le, T. H. Ngo, Y. K. E. Late, P. N. Amaniampong, E. Fletcher, T. Q. Hung, Y. Cheng, T. K. Nguyen, T. S. Tran, J. Zhang, H. An, N. T. Nguyen and Q. T. Trinh |
ChemSusChem, 2024, n/a, e202401974. |
2024 |
|
12. |
Efficient Synthesis of Bis(indolyl)methane Derivatives on Heterogeneous Ga-MCM-41-SO3H Catalyst under Mild Conditions |
D. Van Do, V. T. H. Nguyen, T. T. Linh, T. S. Le, V. Ngoc Binh, H. Nguyen, C.-G. Cho, T. Q. Hung, T. T. Dang and Q. A. Ngo |
Chemistryselect, 2024, 9, e202403150. |
2024 |
|
13. |
FeBr3-catalysed synthesis of 3-aroylimidazo[1,2-a]pyridine and 3,3′-(arylmethylene)bis(2-phenylimidazo[1,2-a]pyridines) derivatives from 2-arylimidazo[1,2-a]pyridines and aromatic aldehydes: an investigation about mechanistic insights |
T. Q. Hung, B. V. Phuc, M. P. Nguyen, T. L. Tran, D. V. Do, H. T. Nguyen, V. T. Nguyen, H. Nguyen and T. T. Dang |
RSC advances, 2024, 14, 29535-29541. |
2024 |
|
14. |
Practical Synthesis of 1,4-Dihydropyridines on Heterogeneous Sulfonic-Modified Silica (SBA-15-SO3H) Catalyst under Mild Condition |
Hung, T. Q. Phuc, B. V. Loan, P. T. T. Thi Lan Nhi, D. Nguyen, H. Xuan Vu, H. Do, D. V. Dang, T. T. |
Curr Org Synth, 2023, 20, 1-1. |
2023 |
|
15. |
Efficient synthesis of 5-aryl-5H-pyrido[2′,1′:2,3]imidazo[4,5-b]indoles by double C N coupling reactions using HKUST-1 as recyclable heterogeneous catalyst under air |
Van Do, Dang Nam Do, Ha Nguyen, Ngoc Khanh Anh Le, Tuan My Le, Tra Van Phuc, Ban Son Le, Thanh Anh Ngo, Quoc Nguyen, Hien Hung, Tran Quang Dang, Tuan Thanh |
Tetrahedron Lett., 2023, 122, 154504. |
2023 |
|
16. |
Practical synthesis of 5H-pyrido[2′,1:2,3]imidazo[4,5-b]indoles by Cu-catalyzed double C–N coupling reactions |
Van Phuc, Ban Dinh, Quang Huy Chi, Nguyen Linh Nguyen, Quyet Tien Nga Truong, Thi Thanh Van Tuyen, Nguyen Nguyen, Hien Langer, Peter Dang, Tuan Thanh Hung, Tran Quang |
Tetrahedron, 2023, 136, 133360. |
2023 |
|
17. |
Facile iodine-promoted synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and exploration of applications |
B. V. Phuc, N. T. Nguyen, N. T. H. Van, T. L. Nguyen, V. H. Nguyen, C. M. Tran, H. Nguyen, M. T. Nguyen, T. Q. Hung and T. T. Dang |
Chem. Commun. (Camb.), 2023, 59, 1947-1950. |
2023 |
|
18. |
Facile access to 5H-thiazolo[2',3':2,3]imidazo[4,5-b]indole derivatives by two-fold Cu-catalysed C-N coupling reactions |
T. Q. Hung, B. C. Q. Nguyen, B. V. Phuc, T. D. Dang Van, C. M. Trang, Q. T. K. Anh, D. V. Do, H. Nguyen, Q. A. Ngo and T. T. Dang |
Org. Biomol. Chem., 2023, DOI: 10.1039/d3ob01515g. |
2023 |
|
19. |
Cu-catalyzed Synthesis of Quinolines by Dehydrogenative Reaction of 2-Aminobenzyl Alcohol and Ketones: A Combined Experimental and Computational Study |
Tuan Ha, M. Thi Nguyen, N. Huyen Tran, N. Viet Ho, Q. Thi Son, N. Nguyen, V. H. Nguyen, H. Van Do, D. Quang Hung, T. Khanh Mai, B. Thanh Dang, T. |
Chemistry – An Asian Journal, 2022, 17, e202200909. |
2022 |
|
20. |
Efficient synthesis of celecoxib and pyrazole derivatives on heterogeneous Ga-MCM-41-SO3H catalyst under mild condition |
Quang-Hung, Tran Do, Tu T. Hoang, Viet Q. Tran, Duc M. Quoc-Anh, Ngo Hoang, Tuan-Anh L. Eckelt, Reinhard Do, Dang V. Dang, Tuan T. Vu, Xuan-Hoan |
Chemical Papers, 2022, 77, 89-99. |
2022 |
|
21. |
Amberlyst-15, an efficient heterogeneous catalyst for the 1,4-dihydropyridine synthesis |
H. Q. Tran, L. T. T. Pham, N. L. T. Do, P. V. Ban, H. T. T. Nguyen, T. T. Dang, T. N. Duong, D. V. Do and H. X. Vu |
Vietnam Journal of Catalysis and Adsorption 2022 Vol. 11 Issue 4 Pages 86-91 |
2022 |
|
22. |
Electrochemical preparation of monodisperse Pt nanoparticles on a grafted 4-aminothiophenol supporting layer for improving the MOR reaction |
N. T. Hoang, P. T. Thuan Nguyen, P. D. Chung, V. T. Thu Ha, T. Q. Hung, P. T. Nam and V. T. Thu |
RSC advances, 2022, 12, 8137-8144. |
2022 |
|
23. |
Practical Copper-catalyzed Synthesis of Pyrroles under Solvent Free Condition |
T. Dang Thanh, S. Nguyen Thi, H. Nguyen, H. Cu Hong, C. Nguyen Thi Thanh, H. Tran Quang, H. Nguyen Thi Thanh, T. Ngo Thi and D. Do Van |
Vietnam Journal of Catalysis and Adsorption 2022 Vol. 11 Issue 3 Pages 54-58 |
2022 |
|
24. |
Research on efficient synthetic method of β- and δ-carbolines using a Copper catalyst |
P. V. Ban, Q. M. Nguyen, H. Nguyen, T. Q. Nguyen, N. T. T. Truong, T. N. Nguyen, A. Q. Nguyen, H. H. Cu, T. D. Thanh and H. Q. Hung |
Vietnam Journal of Catalysis and Adsorption 2022 Vol. 11 Issue 4 Pages 50-56 |
2022 |
|
25. |
Efficient Copper-Catalysed Synthesis of Carbazoles by Double N-Arylation of Primary Amines with 2,2′-Dibromobiphenyl in the Presence of Air |
P. Langer, T. T. Dang, T. Q. Hung, H. N. Do, N. M. Quan, B. Van Phuc, D. Van Tinh, N. Q. Tien, T. T. T. Nga and V. T. Nguyen |
Synlett 2021 Vol. 32 Issue 06 Pages 611-615 |
|
|
26. |
Facile access to bis(indolyl)methanes by copper-catalysed alkylation of indoles using alcohols under air |
N.-K. Nguyen, D. L. Tran, T. Q. Hung, T. M. Le, N. T. Son, Q. T. Trinh, T. T. Dang and P. Langer |
Tetrahedron Letters 2021 Vol. 68 Pages 152936 |
|
|
27. |
Efficient copper-catalyzed synthesis of C3-alkylated indoles from indoles and alcohols |
N.-K. Nguyen, D. H. Nam, B. V. Phuc, V. H. Nguyen, Q. T. Trịnh, T. Q. Hung and T. T. Dang |
Molecular Catalysis 2021 Vol. 505 Pages 111462 |
|
|
28. |
Magnetically recyclable CuFe2O4 catalyst for efficient synthesis of bis(indolyl)methanes using indoles and alcohols under mild condition |
N.-K. Nguyen, M.-T. Ha, H. Y. Bui, Q. T. Trinh, B. N. Tran, V. T. Nguyen, T. Q. Hung, T. T. Dang and X. H. Vu |
Catalysis Communications 2021 Vol. 149 Pages 106240 |
|
|
29. |
Copper-Catalyzed Synthesis of β- and δ-Carbolines by Double N-Arylation of Primary Amines |
P. Langer, T. T. Dang, T. Q. Hung, B. Van Phuc, H. N. Do, N. M. Quan, N. N. Tuan, N. Q. An, N. Van Tuyen |
Synlett 2021 Vol. 32 Issue 10 Pages 1004-1008 |
|
|
30. |
Efficient synthesis of bis(indolyl)methanes by the alkylation of indoles with alcohols using heterogeneous CuFe2O4 catalyst |
T. Ha Minh, Y. Bui Hoang, K. Nguyen Ngoc, T. Ngo Thi, H. Tran Quang, H. Vu Xuan and T. Dang Thanh |
Vietnam Journal of Catalysis and Adsorption 2021 Vol. 10 Issue 3 Pages 98-104 |
|
|
31. |
Limonoids from fruits of Melia dubia cav. in Vietnam |
Tran Trung Hieu, Nguyen Ngọc Tuan, Nguyen Quyet Tien, Nguyen Tan Thanh, Vu Dinh Hoang, Nguyen Thi Nu Trinh, Tran Dinh Thang |
Vietnam Journal of Science and Technology 59 (4) 518-524 |
2021 |
- Intellectual Property:
|
TT |
Patent/Certificate Name |
Inventor(s) |
Issuing Authority |
Date Issued |
Patent/Certificate Number |
|
I |
Utility Solution |
||||
|
1. |
PROCESS FOR SYNTHESIS AND PURIFICATION OF FELODIPINE |
Vu Minh Tan (VN); Le Thi Hong Nhung (VN); Nguyen Ngoc Thanh (VN); Nguyen Quang Tung (VN); Doan Duy Tien (VN); Tran Quang Hung (VN); Ngo Quoc Anh (VN). |
National Office of Intellectual Property of Vietnam (NOIP) |
2021-05-10 |
2654 |
|
2. |
PROCESS FOR PRODUCING A PREPARATION TO SUPPORT THE TREATMENT OF KIDNEY AND GALL STONES FROM LEAVES AND BRANCHES OF COFFEA ARABICA L. AND ENHYDRA FLUCTUANS L. |
Nguyen Quyet Tien, Nguyen Ngoc Tuan, Tran Quang Hung, Truong Thi Thanh Nga, Nguyen Quang An |
National Office of Intellectual Property of Vietnam (NOIP) |
2024-11-24 |
3922 |
|
3. |
