DEPARTMENT OF HETEROCYCLIC CHEMISTRY
- About the lab
Head: Prof. Dr. Ngo Quoc Anh
Tel: 0936807955
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Contact adress: A18 Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, Vietnam
- Lab members:
№ |
Academic Title and Full Name |
Position |
Phone Number |
Email Address |
1 |
Prof. Dr. Ngo Quoc Anh |
Head of Laboratory |
0936807955 |
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2 |
Dr. Nguyen Thi Thanh Tam |
Deputy Head of Laboratory |
0985081601 |
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3 |
Dr. Nguyen Le Anh |
Deputy Head of Laboratory (concurrently) |
0866196566 |
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4 |
Dr. Vo Ngoc Binh |
Staff |
0987543961 |
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5 |
Dr. Tran Duc Quan |
Staff |
0904870167 |
|
6 |
Dr. Nguyen Thi Thuy Hang |
Staff |
0989744369 |
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7 |
Dr. Nguyen Thi Thuy Linh |
Staff |
0986297340 |
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8 |
MSc. Dao Duc Thien |
Staff |
0988501142 |
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9 |
MSc. Tran Thi Yen |
Staff |
0778421799 |
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10 |
MSc. Le Duc Long |
Staff |
0353058696 |
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11 |
MSc. Pham Tung Lam |
Staff |
0824028406 |
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- Research areas:
- Investigation, design, and development of synthetic methods for novel heterocyclic structures
- Focus on applications in biomedical, pharmaceutical, and advanced materials fields
- Design and semi-synthesis heterocyclic compounds from natural products
- International collaboration in pharmaceutical research and development
- Graduate training in Organic Chemistry, Medicinal Chemistry, and Biochemistry
- Main achievements:
- Study on the continuous synthesis process of celecoxib as a raw material for the production of anti-inflammatory and analgesic drugs (Project code: CNHD.ĐT.044/13-14), under the Scientific and Technological Research Program for the Development of the Pharmaceutical Chemistry Industry.
- Completion of celecoxib synthesis technology meeting USP standards at pilot scale, and production of celecoxib capsules on a WHO-GMP certified manufacturing line, under the National Key Science and Technology Program for the Development of the Pharmaceutical Chemistry Industry
- Publications:
№ |
Article Title |
Authors |
Journals |
Year of publication |
1. |
Characterization of volatile components from ethyl acetate extract of Stixis suaveolens (Roxb.) by comprehensive two-dimensional gas chromatography hyphenated with a time-of-flight mass spectrometer |
Ngo Quoc Anh, Hoang Duc Thanh, Tran Thi Yen, Duong Hong Anh, J. Schmitz Oliver, Pham Hung Viet |
Vietnam Journal of Chemistry |
2020 |
2. |
A new method for synthesizing 2-Benzothiazole derivatives from 2-Aminothiophenol and Acetophenone |
Nguyễn Lê Anh, Đoàn Hồng Vân, Ngô Quốc Anh |
Engineering and Technology for Sustainable Development. |
2021 |
3. |
Research on a new method to synthesize 2-arylbenzoxazoles from derivatives of 2-Aminophenol and Benzaldehyde using sulfur as an oxidizing agent. |
Nguyễn Lê Anh, Đặng Thái Duy, Nguyễn Thanh Bình, Ngô Quốc Anh |
Engineering and Technology for Sustainable Development. |
2021 |
4 |
A new method for synthesizing 2-Benzoxazole derivatives from 2-Nitrophenol and Aldehyde. |
Nguyễn Lê Anh, Trần Thị Yến, Ngô Quốc Anh |
Engineering and Technology for Sustainable Development. |
2021 |
5 |
Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitro CCl4-induced toxicity |
Bui Thanh Tung, Nguyen Thanh Hai, Duong Hong Anh, Pham Hung Viet, Oliver J. Schmitz, Nguyen Van Tuyen, Ngo Quoc Anh |
Vietnam Journal of Chemistry |
2021 |
6 |
Synthesis and cytotoxicity of new 4-aza-2,3 didehydropodophyllotoxins. |
Nguyen Thi Thuy Hang, Tran Thi Yen, Vu Dinh Hoang, Ngo Quoc Anh |
Vietnam Journal of Science and Technology |
2022 |
7 |
Synthesis and Cytotoxicity Evaluation of 2-Benzoylbenzoxazoles by Reaction of o-Aminophenol with Acetophenone Catalyzed by Sulfur in DMSO |
Doan Thi Yen Oanh, Tran Thi Yen, Nguyen Le Anh, Ngo Quoc Anh |
Engineering and Technology for Sustainable Development |
2022 |
8 |
Synthesis of thermosensitive e composite gel containing nanocomposite hydrogel applied to extinguish class a fires |
Le Ha Giang, Duong Anh Thanh, Pham Thi Ha My, Pham Thi Thu Trang, Quan Thi Thu Trang, Nguyen Ha Thanh, Pham The Chinh, Nguyen Van Chien, Ngo Quoc Anh |
Journal of Science and Technology |
2023 |
9 |
Determination of Pinoresinol 4-O-beta-D-glucopyranoside and Vladinol F as Markers in Pandanus tonkinensis Fruits by High Performance Liquid Chromatography |
Dinh Thi Huyen Trang, Bui Van Trung, Ngo Quoc Anh, Duong Hong Anh, Pham Hung Viet |
Journal of Science: Medical and Pharmaceutical Sciences |
2023 |
10 |
Sulfur – Promoted Synthesis of Benzoxazoles from 2-Aminophenols and Aldehydes |
Dr. Le Anh Nguyen, Thai Duy Dang, Quoc Anh Ngo, Thanh Binh Nguyen |
European Journal of Organic Chemistry |
2020 |
11 |
Cytokinesis-block micronucleus assay of celecoxib and celecoxib derivatives |
Hauke Reimann, Quoc Anh Ngo, Helga Stopper, Henning Hintzsche |
Toxicology Reports |
2020 |
12 |
Antiproliferative and antiinflammatory coxib–combretastatin hybrids suppress cell cycle progression and induce apoptosis of MCF7 breast cancer cells |
Quoc Anh Ngo, Thuy Hang Nguyen Thi, Minh Quan Pham, Domenico Delfino & Thi Thao Do |
Molecular Diversity |
2020 |
13 |
The catalytic role of elemental sulfur in the DMSO-promoted oxidative coupling of methylhetarenes with amines: synthesis of thioamides and bis-aza-heterocycles Break-and-Build Strategy for the Synthesis of 2-Benzoylbenzoxazoles from o-Aminophenols and Acetophenones |
Thi Thu Tram Nguyen, Le Anh Nguyen, Quoc Anh Ngo, Marina Koleskid and Thanh Binh Nguyen Le Anh Nguyen, Quoc Anh Ngo, Pascal Retailleau, Thanh Binh Nguyen |
Advance Synthetic & Catalysis |
2021 |
14 |
Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines. |
Le Anh Nguyen, Thi Thu Tram Nguyen, Quoc Anh Ngo and Thanh Binh Nguyen |
Organic Biomolecular Chemistry |
2021 |
15 |
Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitro CCl4-induced toxicity |
Bui Thanh Tung, Nguyen Thanh Hai, Duong Hong Anh, Pham Hung Viet, Oliver J. Schmitz, Nguyen Van Tuyen, Ngo Quoc Anh |
Vietnam Journal of Chemistry |
2021 |
16 |
Pandatonkinosides A and B: two new phenolic glycosides from the roots of Pandanus tonkinensis and their nitric oxide production inhibitory activities |
Dinh Thi Huyen Trang, Duong Hong Anh, Quoc Anh Ngo, Pham Hung Viet, Bui Huu Tai, Nguyen Xuan Nhiem & Phan Van Kiem |
Natural Product Research |
2022 |
17 |
Synthesis, antiinflammatory, and cytotoxic activity of novel pyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide derivatives |
Ngoc Binh Vo, Quoc Anh Ngo |
J Heterocyclic Chem. 2022;1–11. |
2022 |
18 |
New 1,4-Dihydropyrazolo[4,3-b]indoles Induce Antiproliferation of Acute Myeloid Leukemia Cells and Inhibition of Selective Inflammatory Cytokines |
Vo Ngoc Binh, Sabrina Adorisio, Quoc Anh Ngo |
Natural Product Communications |
2022 |
19 |
Sulfur-Catalyzed Oxidative Condensation of Aryl Alkyl Ketones with o-Phenylenediamines: Access to Quinoxalines |
Le Anh Nguyen, Thi Thu Tram Nguyen, Quoc Anh Ngo, Thanh Binh Nguyen |
Advance Synthetic & Catalysis |
2023 |
20 |
Lignans and Other Compounds From the Roots of Pandanus tonkinensis and Their Lipid Peroxidation Inhibitory Activity |
Dinh Thi Huyen Trang, Pham Hung Viet, Pham Hung Viet, Duong Hong Anh, Bui Huu Tai, Ngo Quoc Anh, Nguyen Xuan Nhiem and Phan Van Kiem |
Natural Product Communications |
2023 |
21 |
Efficient synthesis of celecoxib and pyrazole derivatives on heterogeneous Ga‑MCM‑41‑SO3H catalyst under mild condition |
Tran Quang‑Hung, Tu T. Do, Viet Q. Hoang, Duc M. Tran, Ngo Quoc‑Anh, Tuan‑Anh L. Hoang, Reinhard Eckelt, Dang V. Do, Tuan T. Dang, Xuan‑Hoan Vu |
Chemical Papers |
2023 |
22 |
Multicomponent synthesis of new 5-thiourea-4-aza-2,3 |
Thi Thuy Hang Nguyen, Le Anh Nguyen, Minh Quan Pham, Ngoc Binh Vo, Quoc Anh Ngo |
J Heterocyclic Chem. 2023; 1–13. |
2023 |
23 |
Recovery of carbon from rice straw for production of high value products by Chlorella sorokiniana TH01 through mixotrophic cultivation |
Cam Van T.Do, Van Toan Lam, Phuong Dung T.Nguyen, Dang Thuan Tran, Quoc Anh Ngo, Truong Gian Le |
Biochemical Engineering Journal |
2023 |
24 |
One-step synthesis of super-absorbent nanocomposite hydrogel based on bentonite |
Giang H Le, Duong A Thanh, Pham T H My, Trang TT Pham, Trang T T Quan, Tung N Nguyen, Quang K Nguyen and Quoc Anh Ngo |
Materials Research Express |
2023 |
25 |
The chemical composition from the fruits of Pandanus tonkinensis, their NO production inhibitory and lipid peroxidation inhibitory activities |
Dinh Thi Huyen Trang, Pham Thu Trang, Do Minh Phuong, Duong Hong Anh, Ngo Quoc Anh, Phan Van Kiem, Pham Hung Viet |
Vietnam Journal of Chemistry |
2023 |
26 |
Efficient synthesis of 5-aryl-5H-pyrido[20,10:2,3]imidazo[4,5-b]indoles by double CAN coupling reactions using HKUST-1 as recyclable heterogeneous catalyst under air |
Dang Van Do, Ha Nam Do, Ngoc Khanh Nguyen, Tuan Anh Le, Tra My Le, Ban Van Phuc, Thanh Son Le, Quoc Anh Ngo, Hien Nguyen, Tran Quan Hung, Tuan Thanh Dang |
Tetrahedron Letters |
2023 |
27 |
Two New Nitrogen-Containing Glycosides From |
Tran Thi Yen, Nguyen Thanh Tam, Nguyen Thanh Thi Kim Vo Ngoc Binh, Nguyen Thao Kim Nu, and Ngo Quoc Anh |
Natural Product Communications |
2023 |
28 |
Fe/S-Catalyzed Redox Condensation of o‑Nitrophenols with Isothiocyanates to 2‑Aminobenzoxazoles |
Le Anh Nguyen, Supasorn Phaenok, Duc Long Le, Thi Thu Tram Nguyen, Quoc Anh Ngo, and Thanh Binh Nguyen |
Organic Letters |
2023 |
29 |
Green synthesis of 2-thioxo-4-quinazolinones from 2-aminobenzamide and isothiocyanates |
Ngoc Binh Vo1 Le Thanh Hang Nguyen2 Thi Yen Tran1 Thi Thuy Hang Nguyen Le Anh Nguyen1 Quoc Anh Ngo |
Vietnam Journal of Chemistry |
2024 |
30 |
Base-Catalyzed Synthesis of N-Aryl Thioacetamides from |
Minh Hang Nguyen, Hai Sam Nguyen, Dr. Le Anh Nguyen, Bich Ngoc Nguyen, Dr. Hai Thuong Cao, Prof. Dr. Dinh Hung Mac, Dr. Thanh Binh Nguyen |
European Journal of Organic Chemistry |
2024 |
31 |
Iron-Promoted Redox Access to 2-Aminobenzoxazoles from Amines, Carbon Disulfide and 2 Nitrophenols |
Duc Long Le, Thi Yen Tran, Le Anh Nguyen, Quoc Anh Ngo, Dinh Hung Mac, Thanh Binh Nguyen |
Asian Journal of Organic Chemistry |
2024 |
32 |
Redox condensation of o-halonitrobenzenes, sulfur and isothiocyanates: access to 2-aminobenzothiazoles |
Le Anh Nguyen, Dinh Hung Mac, Pascal Retailleau, Thanh Binh Nguyen |
Organic & Biomolecular Chemistry |
2024 |
33 |
Sodium sulfide-promoted regiodefined redox condensation of o-nitroanilines with aryl ketones to benzo[a]phenazines and quinoxalines |
Duc Long Le, Le Anh Nguyen, Ngoc Binh Vo, Thi Thu Tram Nguyen, Quoc Anh Ngo, Pascal Retailleau, Thanh Binh Nguyen |
Organic & Biomolecular Chemistry |
2024 |
34 |
Sulfur- and Amine- Promoted Multielectron Autoredox Transformation of Nitromethane: Multicomponent Access to Thiourea Derivatives |
Supasorn Phaenok, Le Anh Nguyen, Darunee Soorukram, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen |
Chemistry – A European Journal |
2024 |
35 |
Sulfur-Promoted Access to 3‑Arylquinoxalin-2-ones by Oxidative Coupling of o‑Phenylenediamines with Arylacetates |
Le Anh Nguyen, Thi Yen Tran, Quoc Anh Ngo, Dinh Hung Mac, Pascal Retailleau, Thanh Binh Nguyen |
Organic Letters |
2024 |
36 |
Efficient Synthesis of Bis(indolyl)methane Derivatives on Heterogeneous Ga-MCM-41-SO3H Catalyst under Mild Conditions |
Hai Yen Nguyen, Thu Hue Tran, Ha Nam Do, Dang Van Do, Quoc-Anh Ngo, Nguyen Quyet Tien, Truong Thi Thanh Nga, Hien Nguyen, Tran Quang Hung, Tuan Thanh Dang |
RSC Advances |
2024 |
37 |
Asymmetric Formal Total Syntheses of (+)- and (−)-Limaspermidine from Chirally Resolved 2‑Pyrone Diels−Alder Cycloadducts via Aromatic C−H Amidation and Imino-Diels−Alder Reaction |
Thanh Binh Nguyen, Thi Yen Tran, Quoc Anh Ngo, Dinh Hung Mac, Pascal Retailleau |
Journal of Organic Chemistry |
2024 |
38 |
Facile access to 5H-thiazolo[2’,3’:2,3]imidazo[4,5-b] indole derivatives by two-fold Cu-catalysed C–N coupling reactions |
Tran Quang Hung, Binh Cuong Quang Nguyen, Binh Vu Phuc, Dang Van Do, Quoc Anh Ngo, Hien Nguyen, Dinh Hung Mac, Thanh Binh Nguyen |
Organic & Biomolecular Chemistry |
2024 |
39 |
LiOtBu-promoted synthesis of bis(3-indolyl) methanes by the alkylation of indoles with alcohols under air |
Hai Yen Nguyen, Thu Hue Tran, Ha Nam Do, Dang Van Do, Quoc-Anh Ngo, Nguyen Quyet Tien, Truong Thi Thanh Nga, Hien Nguyen, Tran Quang Hung, Tuan Thanh Dang |
RSC Advances |
2024 |
40 |
Synthesis and synergistic effect of cuprous(I) oxide nanoparticles and polyethyleneimine modified ammonium polyphosphate on enhancing the flame resistance of epoxy resin |
Hai Thi Doan, Nhiem Thi Nguyen, Nhung Thi Hac, Pham Thi Lan Huong, Mai Ha Hoang, Quoc Anh Ngo, Van Tuyen Nguyen and Vinh Quang Tran |
Materials Research Express |
2023 |
41 |
Immunomodulatory and cytotoxic effects of bergenin and cinchonain Ia isolated from Peltophorum pterocarpum. |
Trinh Thi Thuy, Nguyen Thi Hoang Anh, Do Thi Thao,Domenico V Delfino, Nguyen Thi Thuy Linh |
Journal of Biologically Active Products from Nature |
2023 |
42 |
The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity |
Nguyen Thi Thuy Linh, Nguyen Van Tuyen, Pham Viet Ty, Suresh Awale, Ninh The Son |
Phytochemistry Reviews |
2024 |
43 |
Inhibition of NO Production in LPS-activated RAW264.7 Cells of Stilbenes Isolated from Gnetum latifolium |
Nguyen Thi Thu Hoa, Nguyen Thi Hoang Anh, Trinh Thi Thuy, Domenico V Delfino, Nguyen Thi Thuy Linh |
Journal of Biologically Active Products from Nature |
2024 |
44 |
Identification and nitric oxide production inhibitory activity of phenolic derivatives from the trunks of Gnetum latifolium |
Nguyen Thi Thu Hoa, Ba Thi Cham, Nguyen Thi Hoang Anh, Domenico V Delfino, Trinh Thi Thuy,Nguyen Thi Thuy Linh |
Natural Product Research |
2024 |
45 |
Chemical constituents of Impatiens parvisepala . and their α-glucosidase inhibition activitiy |
Nguyen Thi Thuy Linh,Trinh Thi Thuy, Bui Huu Tai,Do Thi Thao, Nguyen Thi Hoang Anh |
Natural product research |
2023 |
46 |
Chemical constituents of Impatiens chapaensis Tard. and their α-glucosidase inhibition activities |
Nguyen Thi Thuy Linh, Trinh Thi Thuy, Do Thi Thao, Vu Tien Chinh, Nguyen Thi Hoang Anh |
Natural product research |
2021 |
47 |
Medicinal plant Centipeda Minima: A resource of bioactive compounds |
Nguyen Thi Thuy Linh, Nguyen Thi Thu Ha, Nguyen Van Tuyen, Ninh The Son |
Mini-Reviews in Medicinal Chemistry |
2021 |
48 |
Genus Tupistra: A comprehensive review of phytochemistry and pharmacological activity |
Nguyen Thi Thuy Linh, Nguyen Manh Ha, Ninh The Sơn |
Natural product communication |
2022 |
49 |
Components of Impatiens chapaensis growing in Hagiang province, Vietnam and their cytotoxic activity |
Nguyen Thi Thuy Linh, Trinh Thi Thuy, Pham Duc Thang, Vu Tien Chinh, Nguyen Thi Hoang Anh |
Chemistry of Natural Compound |
2023 |
50 |
Flavonoids from aerial parts of Cardiospermum halicacabum L. |
Nguyen Thi Thuy Linh, Ba Thi Cham, Nguyen Thi Hoang Anh, Tran Duc Quan, Domenico V Delfino, Trinh Thi Thuy |
Vietnam Journal of Chemistry |
2023 |
- Photos: