DEPARTMENT OF HETEROCYCLIC CHEMISTRY

 

  1. About the lab

Head:  Prof. Dr. Ngo Quoc Anh

Tel:  0936807955

E-Mail:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact adress: A18 Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, Vietnam

  1. Lab members:

Academic Title and Full Name

Position

Phone Number

Email Address

1

 Prof. Dr. Ngo Quoc Anh

Head of Laboratory

 0936807955

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2

 Dr. Nguyen Thi Thanh Tam

Deputy Head of Laboratory

 0985081601

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3

 Dr. Nguyen Le Anh

Deputy Head of Laboratory (concurrently)

0866196566

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4

 Dr. Vo Ngoc Binh

Staff

 0987543961

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5

Dr. Tran Duc Quan

Staff

0904870167

 

6

Dr. Nguyen Thi Thuy Hang

Staff

0989744369

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7

Dr. Nguyen Thi Thuy Linh

Staff

0986297340

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8

MSc. Dao Duc Thien

Staff

0988501142

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9

MSc. Tran Thi Yen

Staff

0778421799

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10

MSc. Le Duc Long

Staff

0353058696

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11

MSc. Pham Tung Lam

Staff

0824028406

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  1. Research areas:
  • Investigation, design, and development of synthetic methods for novel heterocyclic structures
  • Focus on applications in biomedical, pharmaceutical, and advanced materials fields
  • Design and semi-synthesis heterocyclic compounds from natural products
  • International collaboration in pharmaceutical research and development
  • Graduate training in Organic Chemistry, Medicinal Chemistry, and Biochemistry
  1. Main achievements:
  • Study on the continuous synthesis process of celecoxib as a raw material for the production of anti-inflammatory and analgesic drugs (Project code: CNHD.ĐT.044/13-14), under the Scientific and Technological Research Program for the Development of the Pharmaceutical Chemistry Industry.
  • Completion of celecoxib synthesis technology meeting USP standards at pilot scale, and production of celecoxib capsules on a WHO-GMP certified manufacturing line, under the National Key Science and Technology Program for the Development of the Pharmaceutical Chemistry Industry
  1. Publications:

Article Title

Authors

Journals

Year of publication

1.

 Characterization of volatile components from ethyl acetate extract of Stixis suaveolens (Roxb.) by comprehensive two-dimensional gas chromatography hyphenated with a time-of-flight mass spectrometer

Ngo Quoc Anh, Hoang Duc Thanh, Tran Thi Yen, Duong Hong Anh, J. Schmitz Oliver, Pham Hung Viet

Vietnam Journal of Chemistry

2020

2.

 A new method for synthesizing 2-Benzothiazole derivatives from 2-Aminothiophenol and Acetophenone

Nguyễn Lê Anh, Đoàn Hồng Vân, Ngô Quốc Anh

Engineering and Technology for Sustainable Development.

2021

3.

 Research on a new method to synthesize 2-arylbenzoxazoles from derivatives of 2-Aminophenol and Benzaldehyde using sulfur as an oxidizing agent.

Nguyễn Lê Anh, Đặng Thái Duy, Nguyễn Thanh Bình, Ngô Quốc Anh

Engineering and Technology for Sustainable Development.

 2021

4

A new method for synthesizing 2-Benzoxazole derivatives from 2-Nitrophenol and Aldehyde.

Nguyễn Lê Anh, Trần Thị Yến, Ngô Quốc Anh

Engineering and Technology for Sustainable Development.

2021

5

Hepatoprotective effect of water extract formulation from

Stixis suaveolens and Pandanus tonkinensis against liver injury

induced by acetaminophen and in vitro CCl4-induced toxicity

Bui Thanh Tung, Nguyen Thanh Hai, Duong Hong Anh, Pham Hung Viet, Oliver J. Schmitz, Nguyen Van Tuyen, Ngo Quoc Anh

Vietnam Journal of Chemistry

2021

6

Synthesis and cytotoxicity of new 4-aza-2,3 didehydropodophyllotoxins.

Nguyen Thi Thuy Hang, Tran Thi Yen, Vu Dinh Hoang, Ngo Quoc Anh

Vietnam Journal of Science and Technology

2022

7

Synthesis and Cytotoxicity Evaluation of 2-Benzoylbenzoxazoles

by Reaction of o-Aminophenol with Acetophenone Catalyzed

by Sulfur in DMSO

Doan Thi Yen Oanh, Tran Thi Yen, Nguyen Le Anh, Ngo Quoc Anh

Engineering and Technology for Sustainable Development

2022

8

Synthesis of thermosensitive e composite gel containing nanocomposite hydrogel applied to extinguish class a fires

Le Ha Giang, Duong Anh Thanh, Pham Thi Ha My, Pham Thi Thu Trang, Quan Thi Thu Trang, Nguyen Ha Thanh, Pham The Chinh, Nguyen Van Chien, Ngo Quoc Anh

Journal of Science and Technology

2023

9

Determination of Pinoresinol 4-O-beta-D-glucopyranoside

and Vladinol F as Markers in Pandanus tonkinensis Fruits

by High Performance Liquid Chromatography

Dinh Thi Huyen Trang, Bui Van Trung, Ngo Quoc Anh, Duong Hong Anh, Pham Hung Viet

Journal of Science: Medical and Pharmaceutical Sciences

2023

10

Sulfur – Promoted Synthesis of Benzoxazoles from 2-Aminophenols and Aldehydes

Dr. Le Anh Nguyen, Thai Duy Dang, Quoc Anh Ngo, Thanh Binh Nguyen

European Journal of Organic Chemistry

2020

11

Cytokinesis-block micronucleus assay of celecoxib and

celecoxib derivatives

Hauke Reimann, Quoc Anh Ngo, Helga Stopper, Henning Hintzsche

Toxicology Reports

2020

12

Antiproliferative and antiinflammatory coxib–combretastatin hybrids suppress cell cycle progression and induce apoptosis of MCF7 breast cancer cells

Quoc Anh Ngo, Thuy Hang Nguyen Thi,

Minh Quan Pham, Domenico Delfino &

Thi Thao Do

Molecular Diversity

2020

13

The catalytic role of elemental sulfur in the DMSO-promoted oxidative coupling of methylhetarenes with amines: synthesis of thioamides and bis-aza-heterocycles

Break-and-Build Strategy for the Synthesis of 2-Benzoylbenzoxazoles from o-Aminophenols and Acetophenones

Thi Thu Tram Nguyen, Le Anh Nguyen, Quoc Anh Ngo,  Marina Koleskid  and  Thanh Binh Nguyen

Le Anh Nguyen, Quoc Anh Ngo, Pascal Retailleau, Thanh Binh Nguyen

Advance Synthetic & Catalysis

2021

14

Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines.

Le Anh Nguyen, Thi Thu Tram Nguyen, Quoc Anh Ngo and  Thanh Binh Nguyen

Organic Biomolecular Chemistry

2021

15

Hepatoprotective effect of water extract formulation from

Stixis suaveolens and Pandanus tonkinensis against liver injury

induced by acetaminophen and in vitro CCl4-induced toxicity

Bui Thanh Tung, Nguyen Thanh Hai, Duong Hong Anh, Pham Hung Viet, Oliver J. Schmitz, Nguyen Van Tuyen, Ngo Quoc Anh

Vietnam Journal of Chemistry

2021

16

Pandatonkinosides A and B: two new phenolic

glycosides from the roots of Pandanus tonkinensis

and their nitric oxide production inhibitory

activities

Dinh Thi Huyen Trang, Duong Hong Anh, Quoc Anh Ngo, Pham Hung Viet, Bui Huu Tai, Nguyen Xuan Nhiem & Phan Van Kiem

Natural Product Research

2022

17

Synthesis, antiinflammatory, and cytotoxic activity of novel pyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide derivatives

Ngoc Binh Vo, Quoc Anh Ngo

J Heterocyclic Chem. 2022;1–11.

2022

18

New 1,4-Dihydropyrazolo[4,3-b]indoles Induce Antiproliferation of Acute Myeloid Leukemia Cells and Inhibition of Selective Inflammatory Cytokines

Vo Ngoc Binh, Sabrina Adorisio, Quoc Anh Ngo

Natural Product Communications

2022

19

Sulfur-Catalyzed Oxidative Condensation of Aryl Alkyl Ketones with o-Phenylenediamines: Access to Quinoxalines  

Le Anh Nguyen, Thi Thu Tram Nguyen, Quoc Anh Ngo, Thanh Binh Nguyen

Advance Synthetic & Catalysis

2023

20

Lignans and Other Compounds From the Roots of Pandanus tonkinensis and Their Lipid Peroxidation Inhibitory Activity

Dinh Thi Huyen Trang, Pham Hung Viet, Pham Hung Viet, Duong Hong Anh, Bui Huu Tai, Ngo Quoc Anh, Nguyen Xuan Nhiem and Phan Van Kiem

Natural Product Communications

2023

21

Efficient synthesis of celecoxib and pyrazole derivatives

on heterogeneous Ga‑MCM‑41‑SO3H catalyst under mild condition

Tran Quang‑Hung, Tu T. Do, Viet Q. Hoang, Duc M. Tran, Ngo Quoc‑Anh, Tuan‑Anh L. Hoang, Reinhard Eckelt, Dang V. Do,  Tuan T. Dang,  Xuan‑Hoan Vu

Chemical Papers

2023

22

Multicomponent synthesis of new 5-thiourea-4-aza-2,3
didehydropodophyllotoxins as potent cytotoxic agents

Thi Thuy Hang Nguyen, Le Anh Nguyen, Minh Quan Pham, Ngoc Binh Vo, Quoc Anh Ngo

J Heterocyclic Chem. 2023; 1–13.

2023

23

Recovery of carbon from rice straw for production of high value products by Chlorella sorokiniana TH01 through mixotrophic cultivation

Cam Van T.Do, Van Toan Lam, Phuong Dung T.Nguyen, Dang Thuan Tran, Quoc Anh Ngo, Truong Gian Le

Biochemical Engineering Journal

2023

24

One-step synthesis of super-absorbent nanocomposite hydrogel based on bentonite

Giang H Le, Duong A Thanh, Pham T H My, Trang TT Pham, Trang T T Quan, Tung N Nguyen, Quang K Nguyen and Quoc Anh Ngo

Materials Research Express

2023

25

The chemical composition from the fruits of Pandanus tonkinensis, their NO production inhibitory and lipid peroxidation inhibitory activities

Dinh Thi Huyen Trang, Pham Thu Trang, Do Minh Phuong, Duong Hong Anh, Ngo Quoc Anh, Phan Van Kiem, Pham Hung Viet

Vietnam Journal of Chemistry

2023

26

Efficient synthesis of 5-aryl-5H-pyrido[20,10:2,3]imidazo[4,5-b]indoles

by double CAN coupling reactions using HKUST-1 as recyclable heterogeneous catalyst under air

Dang Van Do, Ha Nam Do, Ngoc Khanh Nguyen, Tuan Anh Le, Tra My Le, Ban Van Phuc, Thanh Son Le, Quoc Anh Ngo, Hien Nguyen, Tran Quan Hung, Tuan Thanh Dang

Tetrahedron Letters

2023

27

Two New Nitrogen-Containing Glycosides From
Stixis scandens

Tran Thi Yen, Nguyen Thanh Tam, Nguyen Thanh Thi Kim Vo Ngoc Binh, Nguyen Thao Kim Nu, and Ngo Quoc Anh

Natural Product Communications

2023

28

Fe/S-Catalyzed Redox Condensation of o‑Nitrophenols with

Isothiocyanates to 2‑Aminobenzoxazoles

Le Anh Nguyen, Supasorn Phaenok, Duc Long Le, Thi Thu Tram Nguyen, Quoc Anh Ngo, and Thanh Binh Nguyen

Organic Letters

2023

29

Green synthesis of 2-thioxo-4-quinazolinones from

2-aminobenzamide and isothiocyanates

Ngoc Binh Vo1 Le Thanh Hang Nguyen2 Thi Yen Tran1 Thi Thuy Hang Nguyen Le Anh Nguyen1 Quoc Anh Ngo

Vietnam Journal of Chemistry

2024

30

Base-Catalyzed Synthesis of N-Aryl Thioacetamides from
Multicomponent Reaction of Phenylacetylenes, Sulfur and
Anilines

Minh Hang Nguyen, Hai Sam Nguyen, Dr. Le Anh Nguyen, Bich Ngoc Nguyen, Dr. Hai Thuong Cao, Prof. Dr. Dinh Hung Mac, Dr. Thanh Binh Nguyen

European Journal of Organic Chemistry

2024

31

Iron-Promoted Redox Access to 2-Aminobenzoxazoles from Amines, Carbon Disulfide and 2 Nitrophenols

Duc Long Le, Thi Yen Tran, Le Anh Nguyen, Quoc Anh Ngo, Dinh Hung Mac, Thanh Binh Nguyen

Asian Journal of Organic Chemistry

2024

32

Redox condensation of o-halonitrobenzenes, sulfur and isothiocyanates: access to 2-aminobenzothiazoles

Le Anh Nguyen, Dinh Hung Mac, Pascal Retailleau, Thanh Binh Nguyen

Organic & Biomolecular Chemistry

2024

33

Sodium sulfide-promoted regiodefined redox

condensation of o-nitroanilines with aryl ketones

to benzo[a]phenazines and quinoxalines

Duc Long Le, Le Anh Nguyen, Ngoc Binh Vo, Thi Thu Tram Nguyen, Quoc Anh Ngo, Pascal Retailleau, Thanh Binh Nguyen

Organic & Biomolecular Chemistry

2024

34

Sulfur- and Amine- Promoted Multielectron Autoredox

Transformation of Nitromethane: Multicomponent Access

to Thiourea Derivatives

Supasorn Phaenok, Le Anh Nguyen, Darunee Soorukram, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen

Chemistry – A European Journal

2024

35

Sulfur-Promoted Access to 3‑Arylquinoxalin-2-ones by Oxidative

Coupling of o‑Phenylenediamines with Arylacetates

Le Anh Nguyen, Thi Yen Tran, Quoc Anh Ngo, Dinh Hung Mac, Pascal Retailleau, Thanh Binh Nguyen

Organic Letters

2024

36

Efficient Synthesis of Bis(indolyl)methane Derivatives on

Heterogeneous Ga-MCM-41-SO3H Catalyst under Mild Conditions

Hai Yen Nguyen, Thu Hue Tran, Ha Nam Do, Dang Van Do, Quoc-Anh Ngo, Nguyen Quyet Tien, Truong Thi Thanh Nga, Hien Nguyen, Tran Quang Hung, Tuan Thanh Dang

RSC Advances

2024

37

Asymmetric Formal Total Syntheses of (+)- and (−)-Limaspermidine

from Chirally Resolved 2‑Pyrone Diels−Alder Cycloadducts via

Aromatic C−H Amidation and Imino-Diels−Alder Reaction

Thanh Binh Nguyen, Thi Yen Tran, Quoc Anh Ngo, Dinh Hung Mac, Pascal Retailleau

Journal of Organic Chemistry

2024

38

Facile access to 5H-thiazolo[2’,3’:2,3]imidazo[4,5-b]

indole derivatives by two-fold Cu-catalysed C–N

coupling reactions

Tran Quang Hung, Binh Cuong Quang Nguyen, Binh Vu Phuc, Dang Van Do, Quoc Anh Ngo, Hien Nguyen, Dinh Hung Mac, Thanh Binh Nguyen

Organic & Biomolecular Chemistry

2024

39

LiOtBu-promoted synthesis of bis(3-indolyl)

methanes by the alkylation of indoles with alcohols

under air

Hai Yen Nguyen, Thu Hue Tran, Ha Nam Do, Dang Van Do, Quoc-Anh Ngo, Nguyen Quyet Tien, Truong Thi Thanh Nga, Hien Nguyen, Tran Quang Hung, Tuan Thanh Dang

RSC Advances

2024

40

Synthesis and synergistic effect of cuprous(I) oxide nanoparticles

and polyethyleneimine modified ammonium polyphosphate on

enhancing the flame resistance of epoxy resin

Hai Thi Doan, Nhiem Thi Nguyen, Nhung Thi Hac, Pham Thi Lan Huong, Mai Ha Hoang, Quoc Anh Ngo, Van Tuyen Nguyen and Vinh Quang Tran

Materials Research Express

2023

41

Immunomodulatory and cytotoxic effects of bergenin and cinchonain Ia isolated from Peltophorum pterocarpum.

Trinh Thi Thuy, Nguyen Thi Hoang Anh, Do Thi Thao,Domenico V Delfino, Nguyen Thi Thuy Linh

Journal of Biologically Active Products from Nature

2023

42

The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity

Nguyen Thi Thuy Linh, Nguyen Van Tuyen, Pham Viet Ty, Suresh Awale, Ninh The Son

Phytochemistry Reviews

2024

43

Inhibition of NO Production in LPS-activated RAW264.7 Cells of Stilbenes Isolated from Gnetum latifolium

Nguyen Thi Thu Hoa, Nguyen Thi Hoang Anh, Trinh Thi Thuy, Domenico V Delfino, Nguyen Thi Thuy Linh

Journal of Biologically Active Products from Nature

2024

44

Identification and nitric oxide production inhibitory activity of phenolic derivatives from the trunks of Gnetum latifolium

Nguyen Thi Thu Hoa, Ba Thi Cham, Nguyen Thi Hoang Anh, Domenico V Delfino, Trinh Thi Thuy,Nguyen Thi Thuy Linh

Natural Product Research

2024

45

Chemical constituents of Impatiens parvisepala . and their α-glucosidase inhibition activitiy

Nguyen Thi Thuy Linh,Trinh Thi Thuy, Bui Huu Tai,Do Thi Thao, Nguyen Thi Hoang Anh

Natural product research

2023

46

Chemical constituents of Impatiens chapaensis Tard. and their α-glucosidase inhibition activities

Nguyen Thi Thuy Linh, Trinh Thi Thuy, Do Thi Thao, Vu Tien Chinh, Nguyen Thi Hoang Anh

Natural product research

2021

47

Medicinal plant Centipeda Minima: A resource of bioactive compounds

Nguyen Thi Thuy Linh, Nguyen Thi Thu Ha,  Nguyen Van Tuyen, Ninh The Son

Mini-Reviews in Medicinal Chemistry

2021

48

Genus Tupistra: A comprehensive review of phytochemistry and pharmacological activity

Nguyen Thi Thuy Linh, Nguyen Manh Ha, Ninh The Sơn

Natural product communication

2022

49

Components of Impatiens chapaensis growing in Hagiang province, Vietnam and their cytotoxic activity

Nguyen Thi Thuy Linh, Trinh Thi Thuy, Pham Duc Thang, Vu Tien Chinh, Nguyen Thi Hoang Anh

Chemistry of Natural Compound

2023

50

Flavonoids from aerial parts of Cardiospermum halicacabum L.

Nguyen Thi Thuy Linh, Ba Thi Cham, Nguyen Thi Hoang Anh, Tran Duc Quan, Domenico V Delfino, Trinh Thi Thuy

Vietnam Journal of Chemistry

2023

  1. Photos:

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