Department of Medicinal Chemistry

DEPARTMENT OF MEDICINAL CHEMISTRY

About the lab Head:

Tel:

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Contact adress: 605, A18, Institute of Chemsitry

Lab members:

No.	Academic title, academic degree and full name	Position	Phone number	E-mail address
1	Prof. Dr. Nguyen Van Tuyen	Senior researcher	0917683979	This email address is being protected from spambots. You need JavaScript enabled to view it.
2	Assoc.Prof.Dr.Đặng Thị Tuyết Anh	Head	0982650338	This email address is being protected from spambots. You need JavaScript enabled to view it.
3	Dr. Lê Nhật Thùy Giang	Deputy Head	0947330356	This email address is being protected from spambots. You need JavaScript enabled to view it.
4	Dr. Nguyễn Hà Thanh	Researcher	0944681199	This email address is being protected from spambots. You need JavaScript enabled to view it.
5	Dr. Nguyễn Thị Quỳnh Giang	Researcher	0914301180	This email address is being protected from spambots. You need JavaScript enabled to view it.
6	Ms. Hoàng Thị Phương	Researcher	0983433926	This email address is being protected from spambots. You need JavaScript enabled to view it.
7	Ms. Nguyễn Tuấn Anh	Researcher	0969207430	This email address is being protected from spambots. You need JavaScript enabled to view it.
8	Ms. Đặng Thị Mai	Researcher	0349759039	This email address is being protected from spambots. You need JavaScript enabled to view it.

Research areas:

- Study on the discovery, transformation and nano-ization of biologically active natural compounds;

- Study on the synthesis of biologically active organic and pharmaceutical compounds;

- Research on application of biotechnology and computational simulation techniques in pharmaceutical chemistry;

- Research on application, transfer and commercialization in the field of pharmaceutical chemistry.

Main achievements:

From 2005 to present, 5 projects under the “national key scientific and technological research program for the development of the pharmaceutical chemistry industry until 2020”, 8 projects under the National Science and Technology Development Fund (Nafosted), 2 projects under the key projects of the Vietnam Academy of Science and Technology (VAST), 1 project assigned by the President to VAST, and 7 international cooperation tasks at VAST with the Russian Foundation for Basic Research successfully accepted.

Currently, the Department of Pharmaceutical Chemistry is implementing 4 projects at the Vietnam Academy of Science and Technology level and 2 projects funded by the National Fund for Science and Technology Development.

In the past 5 years, the Department of Pharmaceutical Chemistry published 35 articles in SCIE, Scopus prestigious international journals (IF > 1.5), 10 articles in specialized national journals.

Publications:

No	Title	Authors	Journal	Time of publication
1.	Three new strategies to the synthesis of structurally diverse dipyrrolobenzodiazepines. bioactivity evaluation	Anna D. Zinoveva, Valeria A. Podchufarova, Tatiana N. Borisova, Anton P. Novikov, Olga V. Levitskaya, Alexander A. Titov, Yana I. Gaponenko, Tuyet Anh Dang Thi, Dao Thi Nhung, Le Tuan Anh, Tuyen Van Nguyen, Alexey V. Varlamov, and Leonid G. Voskressensky	Asian Journal of Organic Chemistry 2025, e202500018	2025
2.	Synthesis, cytotoxicity, apoptosis-inducing activity and molecular docking studies of novel isatin-podophyllotoxin hybrids	Ha Thanh Nguyen, Ket Tran Van, Hai Pham-The, Quang-Bao Le, Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Phuong Hoang Thi, Quynh Giang Nguyen Thi, Anh Nguyen Tuan, Doan Vu Ngoc and Tuyen Van Nguyen	RSC Advances, 2025, 15, 2825	2025
3.	One-pot acid-catalysed synthesis of bis(1-imidazo[1,5-a]pyridyl)arylmethanes and evaluation of cytotoxic activities	Tran Quang Hung, Ban Van Phuc, Ha Nam Do, Thu Hue Tran, Hai Yen Nguyen, Nguyen Truong Phuoc, Truong Mai Chi, Dang Van Do, Truong T. T. Nga, Hien Nguyen, Van Tuyen Nguyen and Tuan Thanh Dang	RSC Advances, 2025, 15, 4274	2025
4.	Improved synthesis, molecular modeling and anti-inflammatory activity of new fluorinated dihydrofurano-naphthoquinone compounds	Ha Thanh Nguyen, Hai Pham-The, Anh Nguyen Tuan, Ha Nguyen Thi Thu, Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Phuong Hoang Thi, Quynh Giang Nguyen Thi, Tuyen Van Nguyen	Bioorganic & Medicinal Chemistry Letters, 104 (2024) 129714	2024
5.	Improved synthesis, molecular modeling and anti-inflammatory activity of new fluorinated dihydrofurano-naphthoquinone compounds	Ha Thanh Nguyen, Hai Pham-The, Anh Nguyen Tuan, Ha Nguyen Thi Thu, Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Phuong Hoang Thi, Quynh Giang Nguyen Thi, Tuyen Van Nguyen	Bioorganic & Medicinal Chemistry Letters, 104 (2024) 129714	2024
6.	Synthesis, in Vitro Α-Glucosidase, and Acetylcholinesterase Inhibitory Activities of Novel Indol-Fused Pyrano [2, 3-D] Pyrimidine Compounds	Nguyen Ha Thanh, Anh Nguyen Tuan, Tuyet Anh Dang Thi, Ket Tran Van, Giang Le-Nhat-Thuy, Phuong Hoang Thi, Quynh Giang Nguyen Thi, Cham Ba Thi, Hung Tran Quang, Tuyen Van Nguyen	Bioorganic & Medicinal Chemistry Letters, 98(2024) 129566	2024
7.	Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents	Ha Thanh Nguyen, Ket Tran Van, Hai Pham-The, Julien Braire, Phuong Hoang Thi, Tuan Anh Nguyen, Quynh Giang Nguyen Thi, Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Tu Anh Le Thi, Doan Vu Ngoc and Tuyen Nguyen Van	RSC Advances, 2024,14,1838	2024
8.	Synthesis of new DOPO derivatives and investigation of their synergistic effect with APP-PEI on the flame retardancy of epoxy composite	Cong Trinh Duc, Linh Chi Nguyen, Phuc Ban Van, Ha Thanh Nguyen, Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Phuong Hoang Thi, Tuan Anh Nguyen, Quang Vinh Tran, Hung Tran Quang, Mai Ha Hoang, and Tuyen Nguyen Van	RSC advances, 14.8 (2024): 5264-5275	2024
9.	Two-step preparation of phosphorus-containing organoclay and its effect on fire-resistant and mechanical properties of the flame-retardant polyethylene composite	Nhung Hac Thi, Toan Van Hoang, Truong Cong Doanh, Ho Thi Oanh, Doan Tien Dat, Ha Tran Nguyen, Giang Le-Nhat-Thuy, Quang Vinh Tran, Mai Ha Hoang, Tuyen Van Nguyen	Journal of Applied Polymer Science, 2024, 141(32), e55758	2024
10.	FeBr₃-catalysed synthesis of 3-aroylimidazo[1,2-a]pyridine and 3,30-(arylmethylene)bis(2-phenylimidazo[1,2-a]pyridines) derivatives from 2-arylimidazo[1,2-a]pyridines and aromatic aldehydes: an investigation about mechanistic insights	Tran Quang Hung, Ban Van Phuc, Mai Phuong Nguyen, Tuan Linh Tran, Dang Van Do, Ha Thanh Nguyen, Van Tuyen Nguyen, Hien Nguyen and Tuan Thanh Dang	RSC advances, 2024, 14(40), 29535-29541	2024
11.	Investigation of the synergistic effect of red phosphorus and magnesium hydroxide on the thermal degradation behavior and flame resistance of the intumescent fire-retardant polypropylene system	Nhung Hac Thi, Truong Cong Doanh, Doan Tien Dat, Ho Thi Oanh, Ha Tran Nguyen, Tuyen Van Nguyen, Quang Vinh Tran, Mai Ha Hoang*	Fire and Materials, 2024, 48.2: 166-179	2024
12.	Practical synthesis of 5H-pyrido [2′, 1: 2, 3] imidazo [4, 5-b] indoles by Cu-catalyzed double C–N coupling reactions	Ban Van Phuc, Quang Huy Dinh, Nguyen Linh Chi, Quyet Tien Nguyen, Thi Thanh Nga Truong, Nguyen Van Tuyen, Hien Nguyen, Peter Langer, Tuan Thanh Dang, Tran Quang Hung	Tetrahedron, 2023, 136, 133360	2023
13.	Microwave-assisted multicomponent synthesis of new 6-arylated 5-hydroxy-benzo[a]phenazine derivatives and their potential anti-inflammatory activity	Ha Thanh Nguyen*, Thu Ha Nguyen Thi, Julien Braire, Tuyet Anh Dang Thi, Tuyen Nguyen Van	ChemistrySelect, 2023, 8.1: e202204376	2023
14.	Synthesis and cytotoxic evaluation of new fluoro and trifluoromethyl substituents containing chromeno[2,3- d]pyrimidines	Ha Thanh Nguyen*, Ha Nguyen Van, Phuong Hoang Thi, Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Anh Nguyen Tuan, Cham Ba Thi, Hung Tran Quang, Tuyen Van Nguyen	Chemistryselect	2023
15.	Preparation of flame retardant polycarbonate-acrylonitrile butadiene styrene composite using graphene nanoplatelets and potassium perfluorobutane sulfonate additives	Quang Vinh Tran, Thi Nhiem Nguyen, Thi Hai Doan, Tuyet Anh Dang Thi, Ha Thanh Nguyen, Mai Ha Hoang, Pham Thi Lan Huong, Van Tuyen Nguyen	Chemistryselect	2023
16.	Synthesis and evaluation of acetylcholinesterase inhibitory and cytotoxic activities of pyrano[2,3-d]pyrimidines	Nguyen Ha Thanh, Nguyen Thi Quynh Giang, Nguyen Van Ha, Hoang Thi Phuong, Le Nhat Thuy Giang, Nguyen Tuan Anh, Ba Thi Cham, Le Duc Huy, Dang Thi Tuyet Anh, Phan Van Kiem, Nguyen Van Tuyen	Natural Product Communications	2023
17.	Investigation of the synergistic effect of red phosphorus and magnesium hydroxide on the thermal degradation behavior and flame resistance of the intumescent fire-retardant polypropylene system	Nhung Hac Thi, Truong Cong Doanh, Doan Tien Dat, Ho Thi Oanh, Ha Tran Nguyen, Tuyen Van Nguyen, Quang Vinh Tran, Mai Ha Hoang*	Fire And Materials	2023
18.	Synthesis of novel γ-butyrolactone-based phenazine compounds via microwave-assisted multicomponent domino reactions	Ha-Thanh Nguyen, Phuong Hoang Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Tuan Anh Nguyen, Tuyet Anh Dang Thi, Tuyen Van Nguyen	Chemistry of Heterocyclic Compounds, 2022, 58.12: 749-755	2022
19.	Synthesis and biological activity, and molecular modelling studies of potent cytotoxic podophyllotoxin-naphthoquinone compounds.	Ha Thanh Nguyen, Quynh Giang Nguyen Thi, Thu Ha Nguyen Thi, Phuong Hoang Thi, Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Bao Le Quang, Hai Pham-The, Tuyen Van Nguyen	RSC Advances, 2022, 12(34), 22004-22019	2022
20.	Microwave-Assisted Three-Component Synthesis of Novel N-Arylated-Dihydrobenzo[g]quinoline-5,10-Diones and Their Potential Cytotoxic Activity	Ha Thanh Nguyen, Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Phuong Hoang Thi, Quynh Giang Nguyen Thi, Tuan Anh Nguyen, Thu Ha Nguyen Thi, Tuyen Van Nguyen	Chemistry and Biodiversity, 2022, 19(8), e202200359.	2022
21.	Bannaxanthone E Induced Cell-cycle Arrest and Apoptosis in Human Lung Cancer Cell Line	Nguyen Ha Thanh, Nguyen Thi Thu Ha, Nguyen Thanh Tra, Le Thi Tu Anh, Ninh The Son, Nguyen Van Tuyen, Phan Van Kiem	Natural Product Communications, 2021, 16.11: 1934578X211059010.	2021
22.	DMAP-catalyzed efficient and convenient approach for the synthesis of 3,3’-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives,	Le Nhat Thuy Giang, Dang Thi Tuyet Anh, Hoang Thi Phuong, Nguyen Ha Thanh, Nguyen Thi Quynh Giang, Nguyen Tuan Anh, Nguyen Van Tuyen and Phan Van Kiem	Natural Product Communications, 2021, 16(9), 1-7	2021
23.	4-(Dimethylamino)pyridine as an efficient catalyst for one-pot synthesis of 1,4-pyranonaphthoquinone derivatives via microwave-assisted multicomponent domino reaction in green solvent	Nguyen Ha Thanh, Hoang Thi Phuong, Le Nhat Thuy Giang, Nguyen Thi Quynh Giang, Nguyen Thi Thu Ha, Dang Thi Tuyet Anh, Nguyen Van Tuyen, Vu Duc Cuong and Phan Van Kiem	Natural Product Communications, 2021, 16(11). 1-7	2021
24.	Novel biopolymer-based nanocomposite food coatings that exhibit active and smart properties due to a single type of nanoparticles	Andreii S Kritchenkov, Anton R Egorov, Olga V Volkova, Alexey A Artemjev, Aleh V Kurliuk, Tuan Anh Le, Hong Hieu Truong, Giang Le-Nhat-Thuy, Thanh Van Tran Thi, Nguyen Van Tuyen, Victor N Khrustalev	Food Chemistry Volume 343, 1 May 2021, 128676	2021
25.	Multicomponent synthesis of novel 3-benzoyl-4h-benzo[g]chromene- 5,10-dione derivatives	Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Phuong Hoang Thi, Quynh Giang Nguyen Thi, Ha-Thanh Nguyen, Doan Vu Ngoc, Tuan-Anh Nguyen, Tuyen Van Nguyen	Tetrahedron Letters, 2021, 75, 153215.	2021
26.	Synthesis and biological evaluation of novel benzo[a]pyridazino[3,4-c]phenazine derivatives	Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Quynh Giang Nguyen Thi, Phuong Hoang Thi, Tuan Anh Nguyen, Ha Thanh Nguyen, Thu Ha Nguyen Thi, Hoang Sa Nguyen, Tuyen Van Nguyen	Bioorganic & Medicinal Chemistry Letters, 2021, Volume 43, 128054.	2021
27.	A new approach for the synthesis of novel naphthoquinone chalcone hybrid compounds	Ha-Thanh Nguyen, Tuyet Anh Dang Thi, Phuong Hoang Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Anh Nguyen Tuan, Tu Anh Le Thi, Tuyen Van Nguyen	Tetrahedron Letters, 2021, available online 19 August 2021, 153337.	2021
28.	Water-soluble triazole chitin derivative and its based nanoparticles: Synthesis, characterization, catalytic and antibacterial properties	Andreii S Kritchenkov, Anton R Egorov, Rimma A Abramovich, Aleh V Kurliuk, Tatsiana V Shakola, Ekaterina K Kultyshkina, Moises J Ballesteros Meza, Anastasia V Pavlova, Elena P Suchkova, Giang Le Nhat Thuy, Nguyen Van Tuyen, Victor N Khrustalev	Carbohydrate Polymers, Volume 257, 1 April 2021, 117593	2021
29.	Copper-Catalyzed Synthesis of β-and δ-Carbolines by Double N-Arylation of Primary Amines	Ban Van Phuc, Ha Nam Do, Nguyen Minh Quan, Nguyen Ngoc Tuan, Nguyen Quang An, Nguyen Van Tuyen, Hoang Le Tuan Anh, Tran Quang Hung, Tuan Thanh Dang, Peter Langer	Synlett 2021; 32(10): 1004-1008	2021
30.	Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component domino reactions and evaluation of their cytotoxic activity	Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Phuong Hoang Thi, Anh Nguyen Tuan, Ha Hoang Mai, Thanh Nguyen Ha, Tuan Anh Le, Tuyen Van Nguyen	Chemistry of Heterocyclic Compounds, 2021, 57(2), 137–142. DOI:	2021
31.	Synthesis of novel potent cytotoxicy podophyllotoxin-naphthoquinone compounds via microwave-assited multicomponent domino reactions	Quynh Giang Nguyen Thi, Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Phuong Hoang Thi, Anh Nguyen Tuan, Thu Ha Nguyen Thi, Thanh Tra Nguyen, Thanh Nguyen Ha, Ha Hoang Mai, Tuyen Van Nguyen	Bioorganic & Medicinal Chemistry Letters, 2021, 37, 127841.	2021
32.	Design, Synthesis, and Cytotoxic Evaluation of Novel Lupane Triterpenoid Derived Hydroxamates	Dang Thi Tuyet Anh, Dinh Thi Cuc, Le Nhat Thuy Giang, Nguyen Thi Hien, Vu Ngoc Doan, Nguyen Ha Thanh, Nguyen Van Tuyen, Phan Van Kiem	June 2020, Natural product communications 15(6):1934578X2093196	2020
33.	Synthesis and biological evaluation of novel quinazoline-triazole hybrid com‐ pounds with potential use in Alzheimer’s disease	Giang Le-Nhat-Thuy, Nga Nguyen Thi, Hai Pham-The, Tuyet Anh Dang Thi, Huong Nguyen Thi, Thu Ha Nguyen Thi, Sa Nguyen Hoang, Tuyen Van Nguyen	· Bioorganic & Medicinal Chemistry Letters, 30(18):127404	2020
34.	Synthesis and Evaluation of the Cytotoxicity of Indeno[1,2-c]Isoquinoline Derivatives Bearing Ester Functional Group and 1,2,3-Triazole Moiety	Hoai Thu Pham, Giang Le-Nhat-Thuy, Tuyet Anh Dang Thi, Phuong Hoang Thi, Tuan Anh Nguyen, Thanh Ha Nguyen, Tien Dung Nguyen, Hanh Thuong Ngo, Tuan Anh Le, Tuyen Van Nguyen	Chemistry of Heterocyclic Compounds (2020), 56(9), 1167-1172	2020
35.	Unexpected synthesis and crystal structure of N-{2-[2-(2-acetylethenyl)phenoxy]ethyl}-N-ethenyl-4-methylbenzenesulfonamide	A. W. Temesgen, M. D. Luong, H. H. Truong, V. T. Nguyen, T. T. A. Dang, T. A. Le, A. G. Tskhovrebov and V. N. Khrustalev	1. Acta Cryst. (2020). E76, 1851-1853	2020