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Vice Head of Lab: Assoc. Prof. Dr. Nguyen Thi Hoang Anh
1. Current members of the Lab
|
No |
Name |
Academic degree |
|
|
1 |
Trinh Thi Thuy |
Assoc. Prof. Dr. |
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|
2 |
Nguyen Thi Hoang Anh |
Assoc. Prof. Dr. |
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|
3 |
Tran Quang Hung |
Dr. |
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|
4 |
Tran Duc Quan |
Dr. |
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|
5 |
Nguyen Thanh Tam |
Dr. |
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|
6 |
Dao Duc Thien |
B.Sc. |
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Research on chemical composition and bioactivity of terrestrial and aquatic plants.
Research and development technology of finished product with high biological activities and high economic value in large scale,based on naturally occurring compounds, semi-synthetic and total synthetic compounds, applying in the field of medicinal, food, perfume, cosmetic, agricultural technology.
Semi-synthesis and total synthesisof the compoundstargeting in organic materials (OLEDs, OTEFs, solar cell), medicine and agriculture.
Research on novel efficient and convenient methodologies of heterocyclic synthesis catalyzed by transition metal.
3. Main achievements
a) Current projects:
|
Project |
Program |
Funding Institution |
Project Leader |
Funded Amount |
Duration |
|
Study on the chemical constituents and biological activities of some selected Pinales species growing in Central highland (Tay Nguyen) of Vietnam |
NAFOSTED |
Ministry-level |
Assoc. Prof. Dr. Trinh Thi Thuy |
800 |
2014-2017 |
|
Study on chemical constituents and biological activities of some endemic and selected species in Ha long bay from the Hedyotis, Allophylus and Chirita genera |
NAFOSTED |
Ministry-level |
Assoc. Prof. Dr. Nguyen Thi Hoang Anh |
800 |
2014-2017 |
|
Studies on technical procedures for preparation of Artocarpus product and active compounds from the leaves of Artocarpus tonkinensis Chev. Ex Gagnep. and its effects on immune system (Cooperation with Italy) |
International cooperation of Science and Technology |
IC Protocol |
Assoc. Prof. Dr. Trinh Thi Thuy |
3400 |
2013-2015 |
|
Study for the detection of compounds with hypoglycaemic activity from Catharanthus roseus (Apocynaceae) in Vietnam |
Science and Technology development program |
VAST-level |
Dr. Nguyen Thanh Tam |
500 |
2013-2014 |
|
Research on process technology of fluoroquinolone antibiotics synthesis |
Pharmaceutical chemistry |
Government-level |
Dr. Tran Duc Quan |
2130 |
2009-2012 |
|
Antifungal, antibacterial, antioxidant, cytotoxic constituents from some vietnamese Eriobotrya species (Rosaceae) |
NAFOSTED |
Ministry-level |
Assoc. Prof. Dr. Nguyen Thi Hoang Anh |
355 |
2009-2012 |
|
Study on chemical constituents and biological activities of selected dye-food-stuff plants of Vietnam |
NAFOSTED |
Ministry-level |
Assoc. Prof. Dr. Trinh Thi Thuy |
466 |
2009-2012 |
|
Study on the isolation, chemical transformation and biological activities of triterpenoids from Acanthopanax trifoliatus (L.) Merr. (Araliaceae) |
NAFOSTED |
Ministry-level |
Dr. Nguyen Thanh Tam |
450 |
2011-2012 |
(Funding Institution: Ministry, Government, IC Protocol, NAFOSTED)
b) List of International and Domestic publications (since 2000)
* International publications:
1) T. N. Ngo; S. A. Ejaz; T. Q. Hung; T. T. Dang; J. Iqbal; J. Lecka; J. Sevigny; P. Langer; Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions Org. Biomol. Chem. 2015, 13(30), 8277-90, 10.1039/c5ob01151e.
2) T. Q. Hung; N. N. Thang; D. H. Hoang; T. T. Dang; K. Ayub; A. Villinger; S. Lochbrunner; G.-U. Flechsig; P. Langer; Synthesis and Properties of 5,7-Dihydropyrido[3,2-b:5,6-b′]diindoles Eur. J. Org. Chem. 2015, 2015(5),1007-19, 10.1002/ejoc.201403035.
3) T. Q. Hung; S. Hancker; A. Villinger; S. Lochbrunner; T. T. Dang; A. Friedrich; W. Breitsprecher; P. Langer; Novel synthesis of 5-methyl-5,10-dihydroindolo[3,2-b]indoles by Pd-catalyzed C-C and two-fold C-N coupling reactions Org. Biomol. Chem. 2015, 13(2),583-91, 10.1039/c4ob01723d.
4) T. Q. Hung; T. T. Dang; J. Janke; A. Villinger; P. Langer; Efficient synthesis of alpha- and delta-carbolines by sequential Pd-catalyzed site-selective C-C and twofold C-N coupling reactions Org. Biomol. Chem. 2015, 13(5),1375-86, 10.1039/c4ob02226b.
5) T. Q. Hung; N. N. Thang; D. H. Hoang; T. T. Dang; A. Villinger; P. Langer; Efficient synthesis of biscarbazoles by palladium-catalyzed twofold C–N coupling and C–H activation reactions Org. Biomol. Chem. 2014, 12(16),2596, 10.1039/c3ob41746h.
6) T. Q. Hung; H. Hoang do; N. N. Thang; T. T. Dang; K. Ayub; A. Villinger; A. Friedrich; S. Lochbrunner; G. U. Flechsig; P. Langer; Palladium catalyzed synthesis and physical properties of indolo[2,3-b]quinoxalines Org. Biomol. Chem. 2014, 12(32),6151-66, 10.1039/c4ob00841c.
7) N. Pozzesi; A. Fierabracci; T. T. Thuy; M. P. Martelli; A. M. Liberati; E. Ayroldi; C. Riccardi; D. V. Delfino; Pharmacological modulation of caspase-8 in thymus-related medical conditions J. Pharmacol. Exp. Ther. 2014, 351(1),18-24, 10.1124/jpet.114.216572.
8) T. T. Thuy; N. T. T. Huong; L. T. H. Nhung; P. T. Ninh; D. V. Delfino; T. Van Sung; Isolation, characterisation and biological evaluation of a phenoxazine, a natural dyestuff isolated from leaves of Peristrophe bivalvis Nat. Prod. Res. 2013, 27(8),771-4, 10.1080/14786419.2012.698409.
9) N. Tam; D. Thien; L. Nhung; T. Van Chien; T. V. Sung; A new lupane triterpenoid from the aerial part of Acanthopanax trifoliatus Chem. Nat. Compd. 2013, 49(2),274-6, 10.1007/s10600-013-0580-6.
10) G. Klatt; R. Xu; M. Pernpointner; L. Molinari; T. Q. Hung; F. Rominger; A. S. Hashmi; H. Koppel; Are beta-H eliminations or alkene insertions feasible elementary steps in catalytic cycles involving gold(I) alkyl species or gold(I) hydrides? Chemistry 2013, 19(12), 3954-61, 10.1002/chem.201203043.
11) T. Q. Hung; T. T. Dang; A. Villinger; T. V. Sung; P. Langer; Efficient synthesis of thieno[3,2-b:4,5-b']diindoles and benzothieno[3,2-b]indoles by Pd-catalyzed site-selective C-C and C-N coupling reactions Org. Biomol. Chem. 2012, 10(45),9041-4, 10.1039/c2ob26489g.
12) T. T. Thuy; T. D. Quan; N. T. Anh; T. V. Sung; Cytotoxic and antimicrobial aporphine alkaloids from Fissistigma poilanei (Annonaceae) collected in Vietnam Nat. Prod. Res. 2012, 26(14),1296-302, 10.1080/14786419.2011.570761.
13) T. T. Thuy; T. H. Lam; N. T. Thanh Huong; L. T. Hong Nhung; P. T. Ninh; N. T. Hoang Anh; T. T. Phuong Thao; T. Van Sung; Natural phenoxazine alkaloids from Peristrophe bivalvis (L.) Merr Biochem. Syst. Ecol. 2012, 44, 205-7, 10.1016/j.bse.2012.05.009.
14) D. G. Thien; N. T. Hoang Anh; A. Porzel; K. Franke; L. Wessjohann; T. Van Sung; Triterpene acids and polyphenols from Eriobotrya poilanei Biochem. Syst. Ecol. 2012, 40, 198-200, 10.1016/j.bse.2011.11.001.
15) V. T. Loc; P. D. Thang; N. T. Anh; P. T. Ninh; T. T. Thuy; V. T. Sung; Novel flavanes from Livistona halongensis Nat. Prod. Commun. 2012, 7(2),179-80,
16) T. T. Thuy; T. D. Quan; N. T. Anh; T. Van Sung; A new hydrochalcone from Miliusa sinensis Nat. Prod. Res.2011, 25(14),1361-5, 10.1080/14786419.2011.569505.
17) N. Pozzesi; S. Pierangeli; C. Vacca; L. Falchi; V. Pettorossi; M. P. Martelli; T. T. Thuy; P. T. Ninh; A. M. Liberati; C. Riccardi; T. V. Sung; D. V. Delfino; Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia J. Chemother.2011, 23(3),150-7, 10.1179/joc.2011.23.3.150.
18) T. T. Minh; N. T. Hoang Anh; V. D. Thang; T. V. Sung; Study on chemical constituent and cytotocic activities of Salacia chinensis growing in Viet nam Z. Naturforsch. 2010, 65b 1284 – 8.
19) H.-K. Cho; N. T. Tam; C.-G. Cho; Total Synthesis of (±)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone Bull. Korean Chem. Soc. 2010, 31(11),3382-4, 10.5012/bkcs.2010.31.11.3382.
20) S.-I. Jung; N.-T. Tam; C.-G. Cho; Bromination/Hydrolytic Fragmentation Reactions of α,β-Unsaturated N-Boc Lactams for the Synthesis of ω-Amino-trisubstituted (E)-Vinyl Bromides Bull. Korean Chem. Soc.2009, 30(12),2863-4, 10.5012/bkcs.2009.30.12.2863.
21) N. T. Tam; C. G. Cho; Total synthesis of (+/-)-crinine via the regioselective Stille coupling and Diels-Alder reaction of 3,5-dibromo-2-pyrone Org. Lett. 2008, 10(4),601-3, 10.1021/ol702907u.
22) N. T. Tam; J. Chang; E.-J. Jung; C.-G. Cho; Total Syntheses of (±)-Crinine, (±)-Crinamine, and (±)-6a-epi-Crinamine via the Regioselective Synthesis and Diels−Alder Reaction of 3-Aryl-5-bromo-2-pyrone J. Org. Chem. 2008, 73(16),6258-64, 10.1021/jo8008353.
23) T. T. Minh; N. T. Hoang Anh; V. D. Thang; T. V. Sung; Constituents of Salacia chinensis L. collected in Vietnam Z. Naturforsch.2008, 63b 1411 – 4.
24) D. T. Huong; N. T. Hong Van; C. Kamperdick; N. T. Hoang Anh; T. V. Sung; Two new Bis-styryl compounds from Miliusa balansae Z. Naturforsch.2008, 63b 335 – 8.
25) N. T. Tam; C. G. Cho; Total synthesis of (+/-)-joubertinamine from 3-(3,4-dimethoxyphenyl)-5-bromo-2-pyrone Org. Lett. 2007, 9(17), 3391-2, 10.1021/ol071381p.
26) T. T. Thuy; T. V. Sung; N. T. Hao; An eudesmane glycoside from Fissistigma pallens Die Pharmazie 2006, 61(6),570-1.
27) T. T. Thuy; A. Porzel; K. Franke; L. Wessjohann; T. V. Sung; Isoquinolone and protoberberine alkaloids from Stephania rotunda Die Pharmazie 2005, 60(9),701-4.
28) N. M. Cuong; T. Q. Hung; T. V. Sung; W. C. Taylor; A New Dimeric Carbazole Alkaloid from Glycosmis stenocarpa Roots Chem. Pharm. Bull. 2004, 52(10),1175-8, 10.1248/cpb.52.1175.
29) T. T. Thuy; C. Kamperdick; P. T. Ninh; T. P. Lien; T. T. Thao; T. V. Sung; Immunosuppressive auronol glycosides from Artocarpus tonkinensis Die Pharmazie 2004, 59(4),297-300.
30) N. T. Hoang Anh; T. Van Sung; A. Porzel; K. Franke; L. A. Wessjohann; Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler Phytochemistry 2003, 62(7),1153-8.
31) N. T. H. Anh; T. V. Sung; K. Franke; L. A. Wessjohann; Phytochemical studies of Rehmannia glutinosa rhizomes Die Pharmazie 2003, 58(8),593-5.
32) T. T. Thuy, H. Ripperger, A. Porzel, T. V. Sung and G. Adam; Coumarins, limonoids and an alkaloid from Clausena excavata Phytochemistry 2010, 52, 511-516.
33) T. T. Thuy, H. Ripperger, A. Porzel, T. V. Sung and G. Adam. Bishordeninyl terpene alkaloids from Zanthoxylum avinennae, Phytochemistry 1999, 50, 903-907.
* National Publication:
1) T. T. Thuy; P. T. Ninh; D. D. Thien; N. Pozzesi; D. V. Delfino; T. V. Sung; The proliferation inhibition of the acute myeloid leukemia cells of astragalin isolated from the leaves of Artocarpus tonkinensis Vietnam Journal of Chemistry 2014, 52(5), 651-3.
2) P. T. Ninh; T. V. Lộc; N. Thế Anh; N. T. Lưu; N. T. Thủy; N. D. Như; T. T. Thủy; T. V. Sung; Preliminary results on phytochemical constituents from Solanum hainanense. Vietnam Vietnam Journal of Chemistry 2014, 52(6A), 1-2.
3) P. T. Ninh; N. T. Liễu; N. T. Hoàng Anh; T. T. Thủy; Đ. T. Phòng; T. V. Sung; Chemical constituents of Keteeleria evelyniana Mast collected in Lam Dong province.Vietnam Journal of Chemistry 2014, 52(6A), 103-6.
4) L. T. H. Nhung; T. T. Thủy; Đ. T. Phòng; T. V. Sung; Isolaciresinol and biological activities of isolated compounds from the root bark of Pinus krempfii LecomteVietnam Journal of Chemistry 2014, 52(6A), 139-42.
5) L. T. H. Nhung; Đ. Đ. Thiện; N. T. Tâm; T. T. Thủy; T. V. Sung; Synthesis and cytotoxic activity of some new oxime derivatives of 24-nor-11α-acid-hydroxy-3-oxo-lup-20 (29)-ene-28-oic isolated from Acanthopanax trifoliatus (L.) Merr.). Vietnam Journal of Chemistry 2014, 52(6A), 3-4.
6) T. T. T. Thủy; T. V. Hiếu; V. T. T. Hà; T. T. Thủy; T. V. Sung; Primary results on the chemical constituentsofthe dichlomethane leaf extract of Tithonia diversifolia (Hemsl.) A. Gray Vietnam Journal of Chemistry 2013, 51(6), 770-3.
7) T. T. Thuy; C. D. Son; P. D. Thinh; T. V. Sung; GC-MS analysis of essential oil and extracts of Zanthoxylum rhetsa (Roxb.) D.C. and their biological activities Vietnam Journal of Chemistry 2013, 51(5A), 27-31.
8) T. T. Thuy; N. T. Hoang Anh; T. V. Sung; T. K. Dan; N. B. Chinh; N. Quang; K. Frank; N. Arnold; L. Wessjohann; Phytochemical study on the plants of the antidrug medication Heantos 4. Part 1. Alkaloids and other nitrogen containing compounds Vietnam Journal of Chemistry 2013, 52(2), 184-8.
9) L. T. H. Nhung; T. T. Thuy; N. T. Tam; D. T. Phong; N. T. Hiep; T. V. Sung; Flavonoids and their biological activities from the rootbark of Pinus krempfii Lecomte Vietnam Journal of Chemistry 2013, 51(5A), 22-6.
10) N. T. Hoang Anh; T. T. Thuy; T. V. Sung; T. K. Dan; N. B. Chinh; N. Quang; K. Frank; N. Arnold; L. Wessjohann; Phytochemical study on the plants of the antidrug medication Heantos 4.Part 4. Phtalides, fatty acids, oligosaccharide esters and miscellaneous compounds Vietnam Journal of Chemistry 2013, 51(5), 546-50.
11) N. T. Hoang Anh; T. T. Thuy; T. V. Sung; T. K. Dan; N. B. Chinh; N. Quang; K. Frank; N. Arnold; L. Wessjohann; Phytochemical study on the plants of the antidrug medication Heantos 4. Part 3. Homoisoflavonoid, flavonoid and phenolic compounds Vietnam Journal of Chemistry 2013, 51(3), 358-62.
12) N. T. Hoang Anh; T. T. Thuy; T. V. Sung; T. K. Dan; N. B. Chinh; N. Quang; K. Frank; N. Arnold; L. Wessjohann; Phytochemical study on the plants of the antidrug medication Heantos 4. Part 2. Terpenoid- and steroid compounds Vietnam Journal of Chemistry 2013, 52(2), 189-93.
13) T. T. Thuy, T. T. P. Thao, K. Frank, L. Wessjohann, T. V. Sung, ; study on chemical constituents from the roots of Codonopsis pilosula Vietnam Journal of Chemistry 2012, 50(1), 116-20.
14) T. T. Thủy; T. H. Lam; N. T. T. Hương; L. T. H. Nhung; P. T. Ninh; N. T. Hoàng Anh; T. V. Sung; Study on the composition and toxicity of the colourant from Peristrophe bivalvis leaves of violete form Vietnam Journal of Chemistry 2012, 50(3),394-7.
15) L. Q. Thắng; T. T. Thuỷ; T. V. Sung; Flavonoids and flavonoid glucosides from Fissistigma balansae (DC.) Merr. Vietnam Journal of Chemistry 2012, 50(1), 77-81.
16) L. Q. Thắng; T. T. Thuỷ; T. V. Sung; Compounds with a C4 chain from Fissistigma rufinerve Vietnam Journal of Chemistry 2012, 50(2B),240-3.
17) T. V. Sung; P. T. Ninh; T. T. Thuy; N. D. Nhu; N. T. Thuy; P. N. Bach; Flavonoids from Gynostemma laxum (Wall.) Cogn. Vietnam Journal of Chemistry 2012, 50(6), 780-4.
18) L. Q. Thắng; T. T. Thuỷ; T. V. Sung; Dihydroflavonol glycosid and aporphine alkaloid from Fississtigma rufinerve Vietnam Journal of Chemistry 2011, 49(1), 70-4.
19) P. T. P. Dung; N. T. T. Hương; T. T. Thủy; T. V. Sung; Lignan, cinnamic amide and flavonon glycoside from wood of Aquilaria sinensis Vietnam Journal of Chemistry 2011, 49(2), 166-71.
20) T. T. Thủy; N. T. T. Hương; T. H. Lam; N. T. Duyên; P. T. Ninh; T. V. Sung; Quantitative analysis and structural elucidation of Peristrophine from the leaves of Peristrophe bilvavis (L.) Merr. Vietnam Journal of Science and Technology2010, 48(6A), 49-54.
21) N. T. T. Hương; T. T. Thủy; Study on extract and purification of pigments from Peristrophe bilvavis (L.) Merr. Journal of Science and Technology of Thai Nguyên University 2010, 74(12), 23-8.
c) Books, Monographs published:
1) T. V.Sung, T. T. Thuy, N. T. H. Anh, Các Hợp chất Thiên nhiên từ một số cây cỏ Việt Nam, Nhà xuất bản Khoa học tự nhiên và Công nghệ, Hà Nội, 2011.
2) N. T. Bình; Đ. T. Tuấn; T. Q. Hưng; T. Q. Hùng; Đ. T. Tùng Tổng hợp hữu cơ (Tập 1); NXB KH&KT, 2014.
d) Patents:
1) T. V. Sung, T. T. Thủy, P. T. Ninh, T. T. P. Thảo, H. N. Anh, N. T. Anh. Utility solution copyright certificate Nr. 1183: “The process of extraction, separation and purification of auronol glucosides possessing bioactivities from leave Artocarpus tonkinensis” Intellectual Property Department, Ministry of Science and Technology, date 02.06.2014.
4. Postgraduatetraining
Supervised 12 fellow Ph.D. (8 graduated)
Supervised 12 fellow M.Sc. (10 graduated)
5. International cooperation
- University of Perugia (Italian Università degli Studi di Perugia), Italy.
- University of Rostock, Germany.
- The Leibniz Institute of Plant Biochemistry (Leibniz-Institut für Pflanzenbiochemie), Germany.
- Hanyang University, Korea.
